deltatrials
Completed PHASE3 INTERVENTIONAL 3-arm NCT02989857

Study of AG-120 in Previously Treated Advanced Cholangiocarcinoma With IDH1 Mutations (ClarIDHy) (ClarIDHy)

A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-controlled Study of AG-120 in Previously-treated Subjects With Nonresectable or Metastatic Cholangiocarcinoma With an IDH1 Mutation

Sponsor: Institut de Recherches Internationales Servier

Conditions Advanced Cholangiocarcinoma Metastatic Cholangiocarcinoma
Interventions AG-120 Placebo
Updated 34 times since 2017 Last updated: Jul 24, 2024 Started: Feb 20, 2017 Primary completion: Jan 31, 2019 Completion: May 17, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Advanced Cholangiocarcinoma and Metastatic Cholangiocarcinoma and is currently completed. Institut de Recherches Internationales Servier leads this study, which shows 34 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jan 2017 – ~Feb 2017 · 31 days · monthly snapshot~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~Jul 2017 · 3 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Mar 2019 · 7 months · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Feb 2023 · 9 months · monthly snapshot~Feb 2023 – ~Jul 2024 · 17 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

34 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Feb 2023 — Jul 2024 [monthly]

    Completed PHASE3

  5. May 2022 — Feb 2023 [monthly]

    Completed PHASE3

▶ Show 29 earlier versions

  1. Apr 2022 — May 2022 [monthly]

    Completed PHASE3

  2. Oct 2021 — Apr 2022 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  3. Jun 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  4. Apr 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  8. Sep 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  9. Jul 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE3

  10. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

  11. Apr 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE3

  12. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

  13. Feb 2020 — Mar 2020 [monthly]

    Active Not Recruiting PHASE3

  14. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  15. Nov 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  16. Sep 2019 — Nov 2019 [monthly]

    Active Not Recruiting PHASE3

  17. Jul 2019 — Sep 2019 [monthly]

    Active Not Recruiting PHASE3

  18. Mar 2019 — Jul 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  19. Aug 2018 — Mar 2019 [monthly]

    Recruiting PHASE3

  20. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  21. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE3

  22. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

  23. Oct 2017 — Nov 2017 [monthly]

    Recruiting PHASE3

  24. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE3

  25. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE3

  26. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE3

  27. Apr 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

  28. Feb 2017 — Apr 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  29. Jan 2017 — Feb 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Institut de Recherches Internationales Servier
Data source: Servier

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Baltimore, United States , Barcelona, Spain , Besançon, France , Bordeaux, France , Boston, United States , Candiolo, Italy , Chicago, United States , Cleveland, United States , Dallas, United States and 27 more locations