deltatrials
Completed PHASE2/PHASE3 INTERVENTIONAL 3-arm NCT03019185

A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome - CARDINAL (CARDINAL)

A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport Syndrome

Sponsor: Biogen

Conditions Alport Syndrome
Interventions Bardoxolone Methyl Placebo Oral Capsule
Updated 23 times since 2017 Last updated: May 26, 2025 Started: Mar 2, 2017 Primary completion: Oct 6, 2020 Completion: Oct 30, 2020
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2/PHASE3 trial investigates Alport Syndrome and is currently completed. Biogen leads this study, which shows 23 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Feb 2017 – ~Mar 2017 · 28 days · monthly snapshot~Mar 2017 – ~Apr 2017 · 31 days · monthly snapshot~Apr 2017 – ~Aug 2017 · 4 months · monthly snapshot~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~May 2018 · 4 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2020 · 13 months · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~Nov 2023 · 19 months · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshot~Jul 2025 – ~Sep 2025 · 2 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

23 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2/PHASE3

  2. Jul 2025 — Sep 2025 [monthly]

    Completed PHASE2/PHASE3

  3. Sep 2024 — Jul 2025 [monthly]

    Completed PHASE2/PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2/PHASE3

    Phase: PHASE2_PHASE3 → PHASE2/PHASE3

  5. Mar 2024 — Jul 2024 [monthly]

    Completed PHASE2_PHASE3

▶ Show 18 earlier versions

  1. Nov 2023 — Mar 2024 [monthly]

    Completed PHASE2_PHASE3

  2. Apr 2022 — Nov 2023 [monthly]

    Completed PHASE2_PHASE3

  3. Oct 2021 — Apr 2022 [monthly]

    Completed PHASE2_PHASE3

  4. Jan 2021 — Oct 2021 [monthly]

    Completed PHASE2_PHASE3

    Status: Active Not Recruiting → Completed

  5. Jan 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  6. Dec 2018 — Jan 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: Recruiting → Active Not Recruiting

  7. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2_PHASE3

  8. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2_PHASE3

  9. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2_PHASE3

  10. Jul 2018 — Sep 2018 [monthly]

    Recruiting PHASE2_PHASE3

  11. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2_PHASE3

  12. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2_PHASE3

  13. Jan 2018 — May 2018 [monthly]

    Recruiting PHASE2_PHASE3

  14. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2_PHASE3

  15. Aug 2017 — Dec 2017 [monthly]

    Recruiting PHASE2_PHASE3

  16. Apr 2017 — Aug 2017 [monthly]

    Recruiting PHASE2_PHASE3

  17. Mar 2017 — Apr 2017 [monthly]

    Recruiting PHASE2_PHASE3

  18. Feb 2017 — Mar 2017 [monthly]

    Recruiting PHASE2_PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Biogen
Data source: Biogen

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Akron, United States , Ann Arbor, United States , Atlanta, United States , Barcelona, Spain , Birmingham, United States , Boston, United States , Caldwell, United States , Cincinnati, United States , Cleveland, United States , Dallas, United States and 47 more locations