deltatrials
Terminated PHASE3 INTERVENTIONAL 1-arm NCT03749447

An Extended Access Program for Bardoxolone Methyl in Patients With CKD (EAGLE) (EAGLE)

An Extended Access Program to Assess Long Term Safety of Bardoxolone Methyl in Patients With Chronic Kidney Disease

Sponsor: Biogen

Conditions Alport Syndrome Autosomal Dominant Polycystic Kidney Chronic Kidney Diseases
Interventions Bardoxolone methyl
Updated 27 times since 2018 Last updated: May 22, 2025 Started: Mar 8, 2019 Primary completion: Aug 23, 2023 Completion: Aug 23, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Discontinuation of all bardoxolone chronic kidney disease programs

Other terminated trials from Biogen

See all terminations from Biogen

Other Alport Syndrome trials with similar outcome

Browse all Alport Syndrome trials

Listed as NCT03749447, this PHASE3 trial focuses on Alport Syndrome and Autosomal Dominant Polycystic Kidney and remains terminated or withdrawn. Sponsored by Biogen, it has been updated 27 times since 2019, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Dec 2018 – ~Apr 2019 · 4 months · monthly snapshot~Apr 2019 – ~Aug 2019 · 4 months · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Jun 2020 · 9 months · monthly snapshot~Jun 2020 – ~Sep 2020 · 3 months · monthly snapshot~Sep 2020 – ~Dec 2020 · 3 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Jan 2022 · 12 months · monthly snapshot~Jan 2022 – ~Jun 2022 · 5 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Nov 2023 · 4 months · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jun 2025 · 9 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

27 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Jun 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Sep 2024 — Jun 2025 [monthly]

    Terminated PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

  5. Apr 2024 — Jul 2024 [monthly]

    Terminated PHASE3

▶ Show 22 earlier versions

  1. Mar 2024 — Apr 2024 [monthly]

    Terminated PHASE3

  2. Jan 2024 — Mar 2024 [monthly]

    Terminated PHASE3

  3. Nov 2023 — Jan 2024 [monthly]

    Terminated PHASE3

  4. Jul 2023 — Nov 2023 [monthly]

    Terminated PHASE3

    Status: Recruiting → Terminated

  5. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE3

  6. Apr 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  7. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  8. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE3

  9. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE3

  10. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  11. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  12. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  13. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  14. Jan 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  15. Jan 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  16. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  17. Sep 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  18. Jun 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  19. Sep 2019 — Jun 2020 [monthly]

    Recruiting PHASE3

  20. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  21. Apr 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  22. Dec 2018 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Biogen
Data source: Biogen

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Arlington, United States , Arvada, United States , Asheville, United States , Atlanta, United States , Aurora, United States , Austin, United States , Baltimore, United States , Barcelona, Spain , Baton Rouge, United States and 68 more locations