deltatrials
Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT03041688

Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia

A Phase 1B Study of KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Acute Myeloid Leukemia

Sponsor: National Cancer Institute (NCI)

Conditions Acute Myeloid Leukemia Recurrent Acute Myeloid Leukemia Refractory Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia
Interventions Biospecimen Collection Bone Marrow Aspiration Bone Marrow Biopsy Decitabine Navtemadlin Venetoclax
Updated 58 times since 2017 Last updated: Mar 12, 2026 Started: Feb 8, 2018 Primary completion: Jun 30, 2026 Completion: Jun 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Acute Myeloid Leukemia and Recurrent Acute Myeloid Leukemia and is currently ongoing. National Cancer Institute (NCI) leads this study, which shows 58 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Feb 2017 – ~May 2017 · 3 months · monthly snapshot~May 2017 – ~Oct 2017 · 5 months · monthly snapshot~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Oct 2020 · 4 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Dec 2021 · 2 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Jul 2022 · 4 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Mar 2023 · 6 months · monthly snapshot~Mar 2023 – ~Sep 2023 · 6 months · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Dec 2023 · 2 months · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Jun 2024 · 3 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Mar 2025 · 5 months · monthly snapshot~Mar 2025 – ~Aug 2025 · 5 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – ~Mar 2026 · 28 days · monthly snapshot~Mar 2026 – present · 6 months · monthly snapshot

Change History

58 versions recorded

  1. Mar 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2026 — Mar 2026 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 53 earlier versions

  1. Oct 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

  2. Sep 2024 — Oct 2024 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  3. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  4. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  5. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  6. Mar 2024 — Jun 2024 [monthly]

    Recruiting PHASE1

  7. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1

  8. Dec 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  9. Oct 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  10. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  11. Mar 2023 — Sep 2023 [monthly]

    Suspended PHASE1

  12. Sep 2022 — Mar 2023 [monthly]

    Suspended PHASE1

  13. Jul 2022 — Sep 2022 [monthly]

    Suspended PHASE1

  14. Mar 2022 — Jul 2022 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  15. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  16. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  17. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  18. Oct 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  19. Jun 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  20. May 2021 — Jun 2021 [monthly]

    Suspended PHASE1

  21. Apr 2021 — May 2021 [monthly]

    Suspended PHASE1

  22. Feb 2021 — Apr 2021 [monthly]

    Suspended PHASE1

  23. Jan 2021 — Feb 2021 [monthly]

    Suspended PHASE1

  24. Dec 2020 — Jan 2021 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  25. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  26. Jun 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  27. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  28. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  29. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  30. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  31. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  32. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  33. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  34. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  35. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  36. Jul 2019 — Aug 2019 [monthly]

    Suspended PHASE1

  37. Jun 2019 — Jul 2019 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  38. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  39. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  40. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  41. Nov 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  42. Sep 2018 — Nov 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  43. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  44. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  45. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  46. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  47. Mar 2018 — May 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  48. Jan 2018 — Mar 2018 [monthly]

    Recruiting PHASE1

  49. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE1

  50. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  51. Oct 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE1

  52. May 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE1

  53. Feb 2017 — May 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations