deltatrials
Recruiting PHASE3 INTERVENTIONAL 5-arm NCT03067181

Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors

Sponsor: Children's Oncology Group

Conditions Childhood Extracranial Germ Cell Tumor Extragonadal Embryonal Carcinoma Germ Cell Tumor Malignant Germ Cell Tumor Malignant Ovarian Teratoma Stage I Ovarian Choriocarcinoma Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7 Stage I Testicular Choriocarcinoma AJCC v6 and v7 Stage I Testicular Embryonal Carcinoma AJCC v6 and v7 Stage I Testicular Seminoma AJCC v6 and v7 Stage I Testicular Yolk Sac Tumor AJCC v6 and v7 Stage II Ovarian Choriocarcinoma Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7 Stage II Testicular Choriocarcinoma AJCC v6 and v7 Stage II Testicular Embryonal Carcinoma AJCC v6 and v7 Stage II Testicular Yolk Sac Tumor AJCC v6 and v7 Stage III Ovarian Choriocarcinoma Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7 Stage III Testicular Choriocarcinoma AJCC v6 and v7 Stage III Testicular Embryonal Carcinoma AJCC v6 and v7 Stage III Testicular Yolk Sac Tumor AJCC v6 and v7 Stage IV Ovarian Choriocarcinoma Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7 Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7 Testicular Mixed Choriocarcinoma and Embryonal Carcinoma Testicular Mixed Choriocarcinoma and Teratoma Testicular Mixed Choriocarcinoma and Yolk Sac Tumor
Interventions Best Practice Biopsy Procedure Biospecimen Collection Bleomycin Sulfate Carboplatin Cisplatin Computed Tomography Etoposide Magnetic Resonance Imaging Pulmonary Function Test Questionnaire Administration
Updated 54 times since 2017 Last updated: Feb 25, 2026 Started: May 25, 2017 Primary completion: Jun 30, 2027 Completion: Jun 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03067181, this PHASE3 trial focuses on Childhood Extracranial Germ Cell Tumor and Extragonadal Embryonal Carcinoma and remains actively recruiting participants. Sponsored by Children's Oncology Group, it has been updated 54 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Jul 2017 · 30 days · monthly snapshot~Jul 2017 – ~Jun 2018 · 11 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Jan 2019 · 4 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Aug 2019 · 3 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Apr 2020 · 4 months · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Mar 2022 · 4 months · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Jun 2022 · 2 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Oct 2023 · 4 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Jan 2025 · 2 months · monthly snapshot~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Jan 2026 · 2 months · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

54 versions recorded

  1. Feb 2026 — Present [monthly]

    Recruiting PHASE3

  2. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE3

  3. Nov 2025 — Jan 2026 [monthly]

    Recruiting PHASE3

  4. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE3

  5. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE3

▶ Show 49 earlier versions

  1. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE3

  2. Apr 2025 — Aug 2025 [monthly]

    Recruiting PHASE3

  3. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE3

  4. Jan 2025 — Mar 2025 [monthly]

    Recruiting PHASE3

  5. Nov 2024 — Jan 2025 [monthly]

    Recruiting PHASE3

  6. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE3

  7. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE3

  8. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  9. Jun 2024 — Jul 2024 [monthly]

    Recruiting PHASE3

  10. May 2024 — Jun 2024 [monthly]

    Recruiting PHASE3

  11. Mar 2024 — May 2024 [monthly]

    Recruiting PHASE3

  12. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE3

  13. Dec 2023 — Feb 2024 [monthly]

    Recruiting PHASE3

  14. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  15. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE3

  16. Jun 2023 — Oct 2023 [monthly]

    Recruiting PHASE3

  17. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE3

  18. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE3

  19. Feb 2023 — Apr 2023 [monthly]

    Recruiting PHASE3

  20. Dec 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  21. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  22. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  23. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  24. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  25. Apr 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  26. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  27. Nov 2021 — Mar 2022 [monthly]

    Recruiting PHASE3

  28. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  29. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  30. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  31. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  32. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  33. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  34. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  35. Jul 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  36. May 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  37. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE3

  38. Dec 2019 — Apr 2020 [monthly]

    Recruiting PHASE3

  39. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  40. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  41. May 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  42. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE3

  43. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  44. Sep 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  45. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  46. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  47. Jul 2017 — Jun 2018 [monthly]

    Recruiting PHASE3

  48. Jun 2017 — Jul 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  49. May 2017 — Jun 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Children's Oncology Group
  • National Cancer Institute (NCI)
Data source: Children's Oncology Group

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Abington, United States , Akron, United States , Albany, United States , Albuquerque, United States , Allentown, United States , Amarillo, United States , Anaheim, United States , Anchorage, United States , Ankeny, United States and 371 more locations