deltatrials
Completed PHASE2 INTERVENTIONAL 3-arm NCT03077412

Study to Evaluate the Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease (Divergence2)

A Phase 2, Double-Blind, Randomized, Placebo-Controlled Study Evaluating the Efficacy and Safety of Filgotinib in the Treatment of Perianal Fistulizing Crohn's Disease

Sponsor: Galapagos NV

Conditions Fistulizing Crohn's Disease
Interventions Filgotinib Placebo to match filgotinib
Updated 46 times since 2017 Last updated: Apr 7, 2022 Started: Apr 6, 2017 Primary completion: Jan 20, 2021 Completion: Feb 17, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Fistulizing Crohn's Disease and is currently completed. Galapagos NV leads this study, which shows 46 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Aug 2017 · 31 days · monthly snapshot~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Oct 2017 · 30 days · monthly snapshot~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Feb 2018 · 2 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Dec 2021 · 8 months · monthly snapshot~Dec 2021 – ~Apr 2022 · 4 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2024 · 26 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

46 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. May 2022 — Jul 2024 [monthly]

    Completed PHASE2

  5. Apr 2022 — May 2022 [monthly]

    Completed PHASE2

▶ Show 41 earlier versions

  1. Dec 2021 — Apr 2022 [monthly]

    Completed PHASE2

  2. Apr 2021 — Dec 2021 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  3. Mar 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE2

  4. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2

  5. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  6. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  7. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  8. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  9. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  10. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  11. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  12. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  13. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  14. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  15. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  16. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  17. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  18. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  19. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  20. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  21. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  22. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  23. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  24. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  25. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  26. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  27. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2

  28. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  29. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  30. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  31. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  32. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  33. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE2

  34. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE2

  35. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  36. Dec 2017 — Feb 2018 [monthly]

    Recruiting PHASE2

  37. Oct 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

  38. Sep 2017 — Oct 2017 [monthly]

    Recruiting PHASE2

  39. Aug 2017 — Sep 2017 [monthly]

    Recruiting PHASE2

  40. Jul 2017 — Aug 2017 [monthly]

    Recruiting PHASE2

  41. May 2017 — Jul 2017 [monthly]

    Recruiting PHASE2

    First recorded

Apr 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Galapagos NV
  • Gilead Sciences
Data source: Gilead Sciences

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Arlington, United States , Baltimore, United States , Békéscsaba, Hungary , Chicago, United States , Columbia, United States , Dresden, Germany , Exeter, United Kingdom , Garland, United States , Germantown, United States , Gyöngyös, Hungary and 16 more locations