deltatrials
Terminated PHASE2 INTERVENTIONAL 3-arm NCT03087708

Naloxegol in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer

A Randomized, Double-Blind, Placebo-Controlled Pilot Study of an Oral, Selective Peripheral Opioid Receptor Antagonist in Advanced Non-Small Cell Lung Cancer

Sponsor: Alliance for Clinical Trials in Oncology

Conditions Stage IIIB Non-Small Cell Lung Cancer Stage IV Non-small Cell Lung Cancer
Interventions Laboratory Biomarker Analysis Naloxegol Placebo Quality-of-Life Assessment
Updated 38 times since 2017 Last updated: Jul 1, 2025 Started: Mar 23, 2018 Primary completion: Jan 4, 2021 Completion: Apr 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Insufficient accrual

Other terminated trials from Alliance for Clinical Trials in Oncology

See all terminations from Alliance for Clinical Trials in Oncology

This PHASE2 trial investigates Stage IIIB Non-Small Cell Lung Cancer and Stage IV Non-small Cell Lung Cancer and is currently terminated or withdrawn. Alliance for Clinical Trials in Oncology leads this study, which shows 38 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~May 2017 – ~Jun 2017 · 31 days · monthly snapshot~Jun 2017 – ~Nov 2017 · 5 months · monthly snapshot~Nov 2017 – ~May 2018 · 6 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Sep 2022 · 15 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Jun 2023 · 5 months · monthly snapshot~Jun 2023 – ~Jul 2024 · 13 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Aug 2025 · 5 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

38 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE2

  2. Aug 2025 — Sep 2025 [monthly]

    Terminated PHASE2

  3. Mar 2025 — Aug 2025 [monthly]

    Terminated PHASE2

  4. Sep 2024 — Mar 2025 [monthly]

    Terminated PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

▶ Show 33 earlier versions

  1. Jun 2023 — Jul 2024 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  2. Jan 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2

  3. Dec 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

  5. Jun 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  6. Feb 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

  7. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

  8. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  9. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  10. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  11. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  12. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2

  13. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  14. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  15. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE2

  16. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  17. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  18. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  19. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  20. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  21. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  22. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  23. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  24. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  25. Oct 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  26. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  27. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  28. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  29. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  30. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Phase: PHASE3 → PHASE2

  31. Nov 2017 — May 2018 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  32. Jun 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE3

    Phase: NA → PHASE3

  33. May 2017 — Jun 2017 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Alliance for Clinical Trials in Oncology
  • National Cancer Institute (NCI)
Data source: Alliance for Clinical Trials in Oncology

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aberdeen, United States , Aitkin, United States , Allentown, United States , American Fork, United States , Ames, United States , Anaconda, United States , Anchorage, United States , Ann Arbor, United States , Arroyo Grande, United States , Ashland, United States and 379 more locations