deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT03107780

Testing the Ability of AMG 232 (KRT 232) to Get Into the Tumor in Patients With Brain Cancer

Phase 0/I Study of AMG 232 (KRT 232) Concentrations in Brain Tissue in Patients With Recurrent Glioblastoma and of AMG 232 (KRT 232) in Combination With Radiation in Patients With Newly Diagnosed Glioblastoma and Unmethylated MGMT Promoters

Sponsor: National Cancer Institute (NCI)

Conditions Glioblastoma Gliosarcoma MGMT-Unmethylated Glioblastoma Recurrent Glioblastoma
Interventions Biospecimen Collection Magnetic Resonance Imaging Navtemadlin Radiation Therapy
Updated 72 times since 2017 Last updated: Nov 12, 2025 Started: Jul 9, 2018 Primary completion: Aug 15, 2025 Completion: Aug 15, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Drug supply issues

Other terminated trials from National Cancer Institute (NCI)

See all terminations from National Cancer Institute (NCI)

Other Glioblastoma trials with similar outcome

Browse all Glioblastoma trials

Listed as NCT03107780, this PHASE1 trial focuses on Glioblastoma and Gliosarcoma and remains terminated or withdrawn. Sponsored by National Cancer Institute (NCI), it has been updated 72 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~May 2017 – ~Nov 2017 · 6 months · monthly snapshot~Nov 2017 – ~Feb 2018 · 3 months · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Apr 2023 · 59 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Jan 2024 · 4 months · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~Aug 2025 · 4 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 9 months · monthly snapshot

Change History

72 versions recorded

  1. Dec 2025 — Present [monthly]

    Terminated PHASE1

  2. Sep 2025 — Dec 2025 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  3. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Apr 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

▶ Show 67 earlier versions

  1. Dec 2024 — Mar 2025 [monthly]

    Suspended PHASE1

  2. Nov 2024 — Dec 2024 [monthly]

    Suspended PHASE1

  3. Oct 2024 — Nov 2024 [monthly]

    Suspended PHASE1

  4. Sep 2024 — Oct 2024 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  5. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  6. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  7. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  8. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1

  9. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE1

  10. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1

  11. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE1

  12. Sep 2023 — Jan 2024 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  13. Jun 2023 — Sep 2023 [monthly]

    Suspended PHASE1

  14. Apr 2023 — Jun 2023 [monthly]

    Suspended PHASE1

  15. Feb 2023 — Apr 2023 [monthly]

    Suspended PHASE1

  16. Nov 2022 — Feb 2023 [monthly]

    Suspended PHASE1

  17. Sep 2022 — Nov 2022 [monthly]

    Suspended PHASE1

  18. Jul 2022 — Sep 2022 [monthly]

    Suspended PHASE1

  19. May 2022 — Jul 2022 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  20. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  21. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  22. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  23. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  24. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  25. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  26. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  27. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  28. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  29. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  30. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  31. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  32. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  33. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  34. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  35. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  36. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  37. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1

  38. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  39. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  40. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  41. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  42. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  43. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  44. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  45. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  46. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  47. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  48. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  49. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  50. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  51. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  52. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  53. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  54. Feb 2019 — Mar 2019 [monthly]

    Suspended PHASE1

  55. Jan 2019 — Feb 2019 [monthly]

    Suspended PHASE1

  56. Dec 2018 — Jan 2019 [monthly]

    Suspended PHASE1

  57. Nov 2018 — Dec 2018 [monthly]

    Suspended PHASE1

  58. Oct 2018 — Nov 2018 [monthly]

    Suspended PHASE1

  59. Sep 2018 — Oct 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  60. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  61. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  62. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1

  63. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  64. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  65. Feb 2018 — Mar 2018 [monthly]

    Not Yet Recruiting PHASE1

  66. Nov 2017 — Feb 2018 [monthly]

    Not Yet Recruiting PHASE1

  67. May 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations