deltatrials
Completed PHASE1 INTERVENTIONAL 2-arm NCT03177291

Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC

A Phase I/Ib Trial of Pirfenidone Combined With Standard First-Line Chemotherapy in Advanced-Stage Lung NSCLC

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Conditions Advanced Cancer Lung Cancer Metastatic Lung Cancer Non Small Cell Lung Cancer Non-Squamous Non-Small Cell Neoplasm of Lung Squamous Cell Lung Cancer
Interventions Carboplatin Paclitaxel Pemetrexed Pirfenidone
Updated 30 times since 2017 Last updated: Dec 4, 2025 Started: Sep 26, 2017 Primary completion: May 9, 2021 Completion: Dec 4, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Advanced Cancer and Lung Cancer and is currently completed. H. Lee Moffitt Cancer Center and Research Institute leads this study, which shows 30 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jul 2017 – ~Oct 2017 · 3 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Nov 2018 · 5 months · monthly snapshot~Nov 2018 – ~Apr 2019 · 5 months · monthly snapshot~Apr 2019 – ~Sep 2019 · 5 months · monthly snapshot~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Jul 2020 · 4 months · monthly snapshot~Jul 2020 – ~Dec 2020 · 5 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Jun 2022 · 5 months · monthly snapshot~Jun 2022 – ~Dec 2022 · 6 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Mar 2024 · 5 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – present · 6 months · monthly snapshot

Change History

30 versions recorded

  1. Jan 2026 — Present [monthly]

    Completed PHASE1

  2. Oct 2025 — Jan 2026 [monthly]

    Completed PHASE1

  3. Jun 2025 — Oct 2025 [monthly]

    Completed PHASE1

  4. Mar 2025 — Jun 2025 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  5. Dec 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 25 earlier versions

  1. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  6. Oct 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Aug 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1

  8. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  9. Dec 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

  10. Jun 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  11. Jan 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1

  12. Sep 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  13. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  14. Mar 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  15. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  16. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  17. Jul 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  18. Mar 2020 — Jul 2020 [monthly]

    Recruiting PHASE1

  19. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  20. Sep 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  21. Apr 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  22. Nov 2018 — Apr 2019 [monthly]

    Recruiting PHASE1

  23. Jun 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  24. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  25. Jul 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lee Moffitt Cancer Center and Research Institute
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations