Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IONIS-MAPTRx in Patients With Mild Alzheimer's Disease
A Randomized, Double-Blind, Placebo-Controlled Study, Followed by an Open-Label Extension, to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Multiple Ascending Doses of Intrathecally Administered ISIS 814907 in Patients With Mild Alzheimer's Disease
Sponsor: Ionis Pharmaceuticals, Inc.
Listed as NCT03186989, this PHASE1 trial focuses on Mild Alzheimer's Disease and remains completed. Sponsored by Ionis Pharmaceuticals, Inc., it has been updated 22 times since 2017, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
22 versions recorded-
Sep 2025 — Present [monthly]
Completed PHASE1
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May 2025 — Sep 2025 [monthly]
Completed PHASE1
Phase: PHASE1/PHASE2 → PHASE1
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Sep 2024 — May 2025 [monthly]
Completed PHASE1/PHASE2
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Jul 2024 — Sep 2024 [monthly]
Completed PHASE1/PHASE2
Phase: PHASE1_PHASE2 → PHASE1/PHASE2
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Mar 2023 — Jul 2024 [monthly]
Completed PHASE1_PHASE2
▶ Show 17 earlier versions
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Nov 2022 — Mar 2023 [monthly]
Completed PHASE1_PHASE2
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Sep 2022 — Nov 2022 [monthly]
Completed PHASE1_PHASE2
Status: Unknown Status → Completed
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Jul 2022 — Sep 2022 [monthly]
Unknown Status PHASE1_PHASE2
Status: Active Not Recruiting → Unknown Status
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Jan 2021 — Jul 2022 [monthly]
Active Not Recruiting PHASE1_PHASE2
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Jul 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE1_PHASE2
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Mar 2020 — Jul 2020 [monthly]
Active Not Recruiting PHASE1_PHASE2
Status: Recruiting → Active Not Recruiting
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Jan 2020 — Mar 2020 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2019 — Jan 2020 [monthly]
Recruiting PHASE1_PHASE2
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Aug 2019 — Sep 2019 [monthly]
Recruiting PHASE1_PHASE2
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Apr 2019 — Aug 2019 [monthly]
Recruiting PHASE1_PHASE2
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Mar 2019 — Apr 2019 [monthly]
Recruiting PHASE1_PHASE2
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Feb 2019 — Mar 2019 [monthly]
Recruiting PHASE1_PHASE2
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Jan 2019 — Feb 2019 [monthly]
Recruiting PHASE1_PHASE2
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Oct 2018 — Jan 2019 [monthly]
Recruiting PHASE1_PHASE2
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Jun 2018 — Oct 2018 [monthly]
Recruiting PHASE1_PHASE2
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Feb 2018 — Jun 2018 [monthly]
Recruiting PHASE1_PHASE2
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Jul 2017 — Feb 2018 [monthly]
Recruiting PHASE1_PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Ionis Pharmaceuticals, Inc.
For direct contact, visit the study record on ClinicalTrials.gov .