deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT03191786

A Study of Atezolizumab Compared With a Single-Agent Chemotherapy in Treatment Naïve Participants With Locally Advanced or Recurrent or Metastatic Non-Small Cell Lung Cancer Who Are Deemed Unsuitable For Platinum-Doublet Chemotherapy (IPSOS)

A Phase III, Open-Label, Multicenter, Randomized Study to Investigate the Efficacy and Safety of Atezolizumab Compared With Chemotherapy in Patients With Treatment Naïve Advanced or Recurrent (Stage IIIb Not Amenable for Multimodality Treatment) or Metastatic (Stage IV) Non-Small Cell Lung Cancer Who Are Deemed Unsuitable for Platinum-Containing Therapy

Sponsor: Hoffmann-La Roche

Conditions Non-Small Cell Lung Cancer
Interventions Atezolizumab (MPDL3280A), an engineered anti-PD-L1 antibody Gemcitabine Vinorelbine
Updated 53 times since 2017 Last updated: Sep 30, 2024 Started: Sep 11, 2017 Primary completion: Apr 30, 2022 Completion: Oct 25, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03191786, this PHASE3 trial focuses on Non-Small Cell Lung Cancer and remains completed. Sponsored by Hoffmann-La Roche, it has been updated 53 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Aug 2017 – ~Sep 2017 · 31 days · monthly snapshot~Sep 2017 – ~Dec 2017 · 3 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~Apr 2018 · 31 days · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Oct 2020 · 3 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Mar 2022 · 3 months · monthly snapshot~Mar 2022 – ~Jun 2022 · 3 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Jan 2023 · 4 months · monthly snapshot~Jan 2023 – ~Jun 2023 · 5 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jul 2024 · 7 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Sep 2025 · 10 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

53 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Nov 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Dec 2023 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

▶ Show 48 earlier versions

  1. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  2. Sep 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  3. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Jan 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  5. Sep 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  7. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  8. Mar 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  9. Dec 2021 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  10. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  11. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  12. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  13. Mar 2021 — May 2021 [monthly]

    Active Not Recruiting PHASE3

  14. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE3

  15. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  16. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE3

  17. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  18. Jul 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE3

  19. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  20. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  21. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  22. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  23. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

  24. Nov 2019 — Dec 2019 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  25. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  26. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  27. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  28. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  29. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  30. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  31. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  32. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  33. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  34. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  35. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  36. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  37. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  38. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  39. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  40. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  41. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  42. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  43. Apr 2018 — May 2018 [monthly]

    Recruiting PHASE3

  44. Mar 2018 — Apr 2018 [monthly]

    Recruiting PHASE3

  45. Jan 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  46. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

  47. Sep 2017 — Dec 2017 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  48. Aug 2017 — Sep 2017 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ahmedabad, India , Almaty, Kazakhstan , Barcelona, Spain , Bebington, United Kingdom , Beijing, China , Bellinzona, Switzerland , Berlin, Germany , Bilbao, Spain , Birmingham, United Kingdom , Bogotá, Colombia and 74 more locations