Active Not Recruiting NA INTERVENTIONAL 1-arm NCT03193801

PARTNER 3 Trial - Mitral Valve in Valve

PARTNER 3 Trial - SAPIEN 3 Transcatheter Heart Valve Implantation in Patients With a Failing Mitral Bioprosthetic Valve

Sponsor: Edwards Lifesciences

Conditions Heart Failure Mitral Valve Disease Mitral Valve Insufficiency Mitral Valve Regurgitation

Interventions Edwards SAPIEN 3 transcatheter valve, Model 9600TFX

Updated 18 times since 2017 Last updated: Oct 31, 2025 Started: Feb 1, 2018 Primary completion: Aug 16, 2022 Completion: Aug 31, 2031

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A NA clinical study on Heart Failure and Mitral Valve Disease, this trial is ongoing. The trial is conducted by Edwards Lifesciences and has accumulated 18 data snapshots since 2018. Cardiovascular trials of this type often inform treatment guidelines for long-term patient management.

Status Flow

Change History

18 versions recorded

Dec 2025 — Present [monthly]

Active Not Recruiting NA
Sep 2025 — Dec 2025 [monthly]

Active Not Recruiting NA
Nov 2024 — Sep 2025 [monthly]

Active Not Recruiting NA
Sep 2024 — Nov 2024 [monthly]

Active Not Recruiting NA
Jul 2024 — Sep 2024 [monthly]

Active Not Recruiting NA

▶ Show 13 earlier versions

Nov 2023 — Jul 2024 [monthly]

Active Not Recruiting NA
Nov 2022 — Nov 2023 [monthly]

Active Not Recruiting NA
Oct 2021 — Nov 2022 [monthly]

Active Not Recruiting NA

Status: Recruiting → Active Not Recruiting
Sep 2021 — Oct 2021 [monthly]

Recruiting NA
Jan 2021 — Sep 2021 [monthly]

Recruiting NA
Nov 2020 — Jan 2021 [monthly]

Recruiting NA
Mar 2020 — Nov 2020 [monthly]

Recruiting NA
Feb 2020 — Mar 2020 [monthly]

Recruiting NA
Feb 2019 — Feb 2020 [monthly]

Recruiting NA
Nov 2018 — Feb 2019 [monthly]

Recruiting NA
Jun 2018 — Nov 2018 [monthly]

Recruiting NA
May 2018 — Jun 2018 [monthly]

Recruiting NA

Status: Not Yet Recruiting → Recruiting
Jul 2017 — May 2018 [monthly]

Not Yet Recruiting NA

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Edwards Lifesciences

Data source: Edwards Lifesciences

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Boston, United States , Cerqueira César, Brazil , Chermside, Australia , Chicago, United States , Evanston, United States , New York, United States , Plano, United States , Portland, United States , Rochester, United States and 2 more locations