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Completed PHASE1 INTERVENTIONAL 1-arm NCT03215810

Nivolumab and Tumor Infiltrating Lymphocytes (TIL) in Advanced Non-Small Cell Lung Cancer

A Phase I Clinical Trial Combining Nivolumab and Tumor Infiltrating Lymphocytes (TIL) for Patients With Advanced Non-Small Cell Lung Cancer

Sponsor: Bristol-Myers Squibb

Conditions Adenocarcinomas Adenosquamous Carcinoma Advanced NSCLC Metastatic Non-small Cell Lung Cancer Non-Small Cell Lung Cancer Squamous Cell Carcinoma
Interventions Cyclophosphamide Fludarabine Interleukin-2 (IL2) Nivolumab Tumor-infiltrating Lymphocyte Therapy Tumor-infiltrating Lymphocytes (TIL)
Updated 25 times since 2017 Last updated: Jul 18, 2023 Started: Oct 11, 2017 Primary completion: Feb 13, 2021 Completion: Jun 9, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03215810, this PHASE1 trial focuses on Adenocarcinomas and Adenosquamous Carcinoma and remains completed. Sponsored by Bristol-Myers Squibb, it has been updated 25 times since 2017, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Aug 2017 – ~Oct 2017 · 2 months · monthly snapshot~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Feb 2019 · 4 months · monthly snapshot~Feb 2019 – ~May 2019 · 3 months · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Dec 2019 · 4 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Nov 2020 · 5 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~May 2022 · 8 months · monthly snapshot~May 2022 – ~Jul 2022 · 2 months · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

25 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1

  3. Aug 2023 — Jul 2024 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  4. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Dec 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE1

▶ Show 20 earlier versions

  1. Jul 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  2. May 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2021 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  4. Apr 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE1

  5. Feb 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE1

  6. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE1

  7. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  8. Jun 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE1

  9. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

  10. Mar 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  11. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  12. Dec 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  13. Aug 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  14. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  15. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  16. Feb 2019 — May 2019 [monthly]

    Recruiting PHASE1

  17. Oct 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

  18. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE1

  19. Oct 2017 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  20. Aug 2017 — Oct 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bristol-Myers Squibb
  • H. Lee Moffitt Cancer Center and Research Institute
  • Iovance Biotherapeutics, Inc.
  • Prometheus Inc.
  • Stand Up To Cancer
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations