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Active Not Recruiting PHASE1 INTERVENTIONAL 1-arm NCT05681780

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

Clinical Trial of CD40L-augmented Tumor Infiltrating Lymphocytes (CD40L TIL) for Patients With Oncogene-Driven Advanced Non-Small Cell Lung Cancer (NSCLC)

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Updated 12 times since 2023 Last updated: Dec 2, 2025 Started: Mar 10, 2023 Primary completion: Dec 31, 2025 Completion: Dec 31, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT05681780, this PHASE1 trial focuses on Non Small Cell Lung Cancer and Recurrent Non Small Cell Lung Cancer and remains ongoing. Sponsored by H. Lee Moffitt Cancer Center and Research Institute, it has been updated 12 times since 2023, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Feb 2023 – ~Jun 2023 · 4 months · monthly snapshotRecruiting~Jun 2023 – ~Oct 2023 · 4 months · monthly snapshotRecruiting~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshotRecruiting~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshotRecruiting~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshotRecruiting~Jan 2025 – ~Mar 2025 · 59 days · monthly snapshotRecruiting~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshotRecruiting~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshotRecruiting~Sep 2025 – ~Jan 2026 · 4 months · monthly snapshotActive Not Recruiting~Jan 2026 – present · 6 months · monthly snapshotActive Not Recruiting

Change History

12 versions recorded
  1. Jan 2026 — Present [monthly]

    Active Not Recruiting PHASE1

  2. Sep 2025 — Jan 2026 [monthly]

    Active Not Recruiting PHASE1

    Status: RecruitingActive Not Recruiting

  3. Jun 2025 — Sep 2025 [monthly]

    Recruiting PHASE1

    Phase: PHASE1/PHASE2PHASE1

  4. Mar 2025 — Jun 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Jan 2025 — Mar 2025 [monthly]

    Recruiting PHASE1/PHASE2

Show 7 earlier versions
  1. Sep 2024 — Jan 2025 [monthly]

    Recruiting PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2PHASE1/PHASE2

  3. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE1_PHASE2

  4. Nov 2023 — Apr 2024 [monthly]

    Recruiting PHASE1_PHASE2

  5. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1_PHASE2

  6. Jun 2023 — Oct 2023 [monthly]

    Recruiting PHASE1_PHASE2

  7. Feb 2023 — Jun 2023 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lee Moffitt Cancer Center and Research Institute
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations