deltatrials
Completed PHASE2 INTERVENTIONAL 4-arm NCT03222609

A Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Participants With Myelofibrosis (REFINE)

A Phase 2 Open-Label Study Evaluating Tolerability and Efficacy of Navitoclax Alone or in Combination With Ruxolitinib in Subjects With Myelofibrosis (REFINE)

Sponsor: AbbVie

Conditions Myelofibrosis (MF)
Interventions Navitoclax Ruxolitinib
Updated 40 times since 2017 Last updated: Dec 29, 2025 Started: Oct 31, 2017 Primary completion: Mar 28, 2022 Completion: Jan 29, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates Myelofibrosis (MF) and is currently completed. AbbVie leads this study, which shows 40 recorded versions since 2017 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Aug 2017 – ~Dec 2017 · 4 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Oct 2019 · 4 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Jun 2020 · 3 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Jul 2024 · 15 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – ~Feb 2026 · 2 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

40 versions recorded

  1. Feb 2026 — Present [monthly]

    Completed PHASE2

  2. Dec 2025 — Feb 2026 [monthly]

    Completed PHASE2

  3. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE2

  4. Apr 2025 — Sep 2025 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Sep 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 35 earlier versions

  1. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Apr 2023 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  4. Dec 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  6. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  7. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  8. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  9. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  10. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  11. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  12. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  13. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  14. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  15. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  16. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE2

  17. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  18. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE2

  19. Mar 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  20. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  21. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  22. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  23. Jun 2019 — Oct 2019 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  24. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  25. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  26. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  27. Oct 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  28. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  29. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  30. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  31. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

  32. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

  33. Jan 2018 — Mar 2018 [monthly]

    Recruiting PHASE2

  34. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  35. Aug 2017 — Dec 2017 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AbbVie
Data source: AbbVie

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Abilene, United States , Aomori, Japan , Ashdod, Israel , Athens, Greece , Badalona, Spain , Barcelona, Spain , Belfast, United Kingdom , Bend, United States , Bergamo, Italy , Bethesda, United States and 67 more locations