deltatrials
Completed PHASE3 INTERVENTIONAL 2-arm NCT04472598

Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis (TRANSFORM-1)

A Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study Of Navitoclax In Combination With Ruxolitinib Versus Ruxolitinib In Subjects With Myelofibrosis (TRANSFORM-1)

Sponsor: AbbVie

Updated 31 times since 2020 Last updated: Feb 18, 2025 Started: Sep 29, 2020 Primary completion: Apr 13, 2023 Completion: Jan 29, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Myelofibrosis (MF) and is currently completed. AbbVie leads this study, which shows 31 recorded versions since 2020 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Jun 2021 · 2 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~May 2023 · 3 months · monthly snapshot~May 2023 – ~Apr 2024 · 11 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Sep 2025 · 6 months · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

31 versions recorded
  1. Dec 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2025 — Dec 2025 [monthly]

    Completed PHASE3

  3. Mar 2025 — Sep 2025 [monthly]

    Completed PHASE3

    Status: Active Not RecruitingCompleted

  4. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE3

Show 26 earlier versions
  1. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE3

  2. May 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Feb 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  4. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

    Status: RecruitingActive Not Recruiting

  5. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE3

  6. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  7. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE3

  8. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE3

  9. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE3

  10. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE3

  11. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE3

  12. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE3

  13. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE3

  14. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE3

  15. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE3

  16. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE3

  17. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  18. Apr 2021 — Jun 2021 [monthly]

    Recruiting PHASE3

  19. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE3

  20. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  21. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  22. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  23. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  24. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  25. Sep 2020 — Oct 2020 [monthly]

    Not Yet Recruiting PHASE3

  26. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AbbVie
Data source: AbbVie

For direct contact, visit the study record on ClinicalTrials.gov .