deltatrials
Completed PHASE4 INTERVENTIONAL 2-arm NCT03241641

Switching From TDF to TAF vs. Maintaining TDF in Chronic Hepatitis B With Resistance to Adefovir or Entecavir.

Switching From Tenofovir Disoproxil Fumarate(TDF) to Tenofovir AlaFenamide(TAF) vs. Maintaining TDF Monotherapy in Chronic Hepatitis B Patients With Genotypic Resistance to Adefovir or Entecavir

Sponsor: Konkuk University Medical Center

Conditions Chronic Hepatitis b
Interventions Tenofovir Alafenamide Tenofovir Disoproxil Fumarate
Updated 11 times since 2017 Last updated: Mar 25, 2021 Started: Oct 26, 2017 Primary completion: Mar 25, 2021 Completion: Mar 25, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Chronic Hepatitis b and is currently completed. Konkuk University Medical Center leads this study, which shows 11 recorded versions since 2017 — indicating substantial longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Sep 2017 – ~Nov 2017 · 2 months · monthly snapshotNot Yet Recruiting~Nov 2017 – ~Jun 2018 · 7 months · monthly snapshotRecruiting~Jun 2018 – ~Jan 2019 · 7 months · monthly snapshotRecruiting~Jan 2019 – ~Feb 2020 · 13 months · monthly snapshotActive Not Recruiting~Feb 2020 – ~Aug 2020 · 6 months · monthly snapshotActive Not Recruiting~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshotActive Not Recruiting~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshotActive Not Recruiting~Apr 2021 – ~Jul 2024 · 39 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 12 months · monthly snapshotCompleted

Change History

11 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE4

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE4

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  4. Apr 2021 — Jul 2024 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  5. Jan 2021 — Apr 2021 [monthly]

    Active Not Recruiting PHASE4

▶ Show 6 earlier versions

  1. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE4

  2. Feb 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE4

  3. Jan 2019 — Feb 2020 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  4. Jun 2018 — Jan 2019 [monthly]

    Recruiting PHASE4

  5. Nov 2017 — Jun 2018 [monthly]

    Recruiting PHASE4

    Status: Not Yet Recruiting → Recruiting

  6. Sep 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE4

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Konkuk University Medical Center
  • Korea University Guro Hospital
  • Samsung Medical Center
  • Seoul National University Hospital
  • Young-Suk Lim
Data source: Asan Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations