deltatrials
Active Not Recruiting OBSERVATIONAL NCT03281902

Genetic Analysis in Blood and Tumor Samples From Patients With Advanced or Metastatic Estrogen Receptor Positive and HER2 Negative Breast Cancer Receiving Palbociclib and Endocrine Therapy

Prospective Study to Evaluate the Role of Tumor Sequencing in Women Receiving Palbociclib for Advanced Hormone Receptor (HR)-Positive, Breast Cancer (PROMISE)

Sponsor: Mayo Clinic

Conditions Advanced Breast Carcinoma Locally Advanced Breast Carcinoma Metastatic Breast Carcinoma Recurrent Breast Carcinoma Stage III Breast Cancer AJCC v7 Stage IIIA Breast Cancer AJCC v7 Stage IIIB Breast Cancer AJCC v7 Stage IIIC Breast Cancer AJCC v7 Stage IV Breast Cancer AJCC v6 and v7
Interventions Biopsy Biospecimen Collection Laboratory Biomarker Analysis
Updated 21 times since 2017 Last updated: Mar 4, 2025 Started: Nov 13, 2017 Primary completion: Mar 4, 2026 Completion: Mar 4, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A observational or N/A phase clinical study on Advanced Breast Carcinoma and Locally Advanced Breast Carcinoma, this trial is ongoing. The trial is conducted by Mayo Clinic and has accumulated 21 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Oct 2017 – ~Dec 2017 · 2 months · monthly snapshot~Dec 2017 – ~Apr 2018 · 4 months · monthly snapshot~Apr 2018 – ~May 2018 · 30 days · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jun 2019 · 12 months · monthly snapshot~Jun 2019 – ~Sep 2019 · 3 months · monthly snapshot~Sep 2019 – ~Aug 2020 · 11 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Sep 2022 · 9 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Jul 2023 · 5 months · monthly snapshot~Jul 2023 – ~Nov 2023 · 4 months · monthly snapshot~Nov 2023 – ~Jan 2024 · 2 months · monthly snapshot~Jan 2024 – ~Jul 2024 · 6 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – present · 16 months · monthly snapshot

Change History

21 versions recorded

  1. Apr 2025 — Present [monthly]

    Active Not Recruiting

  2. Sep 2024 — Apr 2025 [monthly]

    Active Not Recruiting

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting

  4. Jan 2024 — Jul 2024 [monthly]

    Active Not Recruiting

  5. Nov 2023 — Jan 2024 [monthly]

    Active Not Recruiting

▶ Show 16 earlier versions

  1. Jul 2023 — Nov 2023 [monthly]

    Active Not Recruiting

  2. Feb 2023 — Jul 2023 [monthly]

    Active Not Recruiting

  3. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting

  4. Dec 2021 — Sep 2022 [monthly]

    Active Not Recruiting

  5. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting

    Status: Suspended → Active Not Recruiting

  6. Apr 2021 — Sep 2021 [monthly]

    Suspended

  7. Jan 2021 — Apr 2021 [monthly]

    Suspended

  8. Nov 2020 — Jan 2021 [monthly]

    Suspended

  9. Aug 2020 — Nov 2020 [monthly]

    Suspended

    Status: Recruiting → Suspended

  10. Sep 2019 — Aug 2020 [monthly]

    Recruiting

  11. Jun 2019 — Sep 2019 [monthly]

    Recruiting

  12. Jun 2018 — Jun 2019 [monthly]

    Recruiting

  13. May 2018 — Jun 2018 [monthly]

    Recruiting

  14. Apr 2018 — May 2018 [monthly]

    Recruiting

    Phase: NA → None

  15. Dec 2017 — Apr 2018 [monthly]

    Recruiting NA

    Status: Not Yet Recruiting → Recruiting

  16. Oct 2017 — Dec 2017 [monthly]

    Not Yet Recruiting NA

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • National Cancer Institute (NCI)
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations