deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT03283397

A Phase IIIb, Multicenter, International Study to Evaluate the Efficacy, Safety and Tolerability of EK-12 in Patients With RRMS

A Phase IIIb, Multi-center, International, Randomized, Assessor-blind, Active-controlled Parallel Arm Clinical Study to Evaluate the Efficacy, Safety and Tolerability of Neuropeptide Combination of Metenkefalin and Tridecactide (EK-12) in Comparison to Interferon Beta-1a (REBIF®) in Patients With Relapsing Remitting Multiple Sclerosis (RRMS)

Sponsor: Bosnalijek D.D

Updated 9 times since 2017 Last updated: Aug 11, 2024 Started: Mar 26, 2019 Primary completion: Jul 1, 2023 Completion: Jul 1, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

During the Covid-19 pandemic, the study was unable to enrol further patients.

Listed as NCT03283397, this PHASE3 trial focuses on Multiple Sclerosis, Relapsing-Remitting and remains terminated or withdrawn. Sponsored by Bosnalijek D.D, it has been updated 9 times since 2019, reflecting limited change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Oct 2017 – ~Jun 2018 · 8 months · monthly snapshotNot Yet Recruiting~Jun 2018 – ~May 2020 · 23 months · monthly snapshotNot Yet Recruiting~May 2020 – ~Jan 2021 · 8 months · monthly snapshotRecruiting~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshotRecruiting~Sep 2021 – ~Mar 2023 · 18 months · monthly snapshotRecruiting~Mar 2023 – ~Jul 2024 · 16 months · monthly snapshotRecruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotRecruiting~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotTerminated~Sep 2025 – present · 10 months · monthly snapshotTerminated

Change History

9 versions recorded
  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Terminated PHASE3

    Status: RecruitingTerminated

  3. Jul 2024 — Sep 2024 [monthly]

    Recruiting PHASE3

  4. Mar 2023 — Jul 2024 [monthly]

    Recruiting PHASE3

  5. Sep 2021 — Mar 2023 [monthly]

    Recruiting PHASE3

Show 4 earlier versions
  1. Jan 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  2. May 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

    Status: Not Yet RecruitingRecruiting

  3. Jun 2018 — May 2020 [monthly]

    Not Yet Recruiting PHASE3

  4. Oct 2017 — Jun 2018 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Bosnalijek D.D
  • MonitorCRO
Data source: Bosnalijek D.D

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations