deltatrials
Completed PHASE1 INTERVENTIONAL 5-arm NCT03289962

A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors

A Phase 1a/1b Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of RO7198457 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Tumors

Sponsor: BioNTech SE

Conditions Bladder Cancer Colorectal Cancer Head and Neck Cancer Melanoma Non-Small Cell Lung Cancer Other Solid Cancers Renal Cancer Triple Negative Breast Cancer
Interventions Atezolizumab Autogene cevumeran
Updated 57 times since 2017 Last updated: Jul 3, 2025 Started: Dec 21, 2017 Primary completion: Jul 1, 2025 Completion: Jul 1, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Bladder Cancer and Colorectal Cancer and is currently completed. BioNTech SE leads this study, which shows 57 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Mar 2018 · 3 months · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Nov 2018 · 3 months · monthly snapshot~Nov 2018 – ~Mar 2019 · 4 months · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Jan 2023 · 3 months · monthly snapshot~Jan 2023 – ~Apr 2023 · 3 months · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Sep 2023 · 3 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Feb 2024 · 2 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Feb 2025 · 2 months · monthly snapshot~Feb 2025 – ~Apr 2025 · 59 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Aug 2025 · 3 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

57 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE1

  2. Aug 2025 — Sep 2025 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  3. May 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Apr 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE1

  5. Feb 2025 — Apr 2025 [monthly]

    Active Not Recruiting PHASE1

▶ Show 52 earlier versions

  1. Dec 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE1

  2. Nov 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Aug 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2024 — Aug 2024 [monthly]

    Active Not Recruiting PHASE1

  6. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

  7. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1

  8. Dec 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE1

  9. Sep 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE1

  10. Jun 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE1

  11. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1

  12. Jan 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE1

  13. Oct 2022 — Jan 2023 [monthly]

    Active Not Recruiting PHASE1

  14. Sep 2022 — Oct 2022 [monthly]

    Active Not Recruiting PHASE1

  15. May 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  16. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE1

  17. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  18. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  19. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  20. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  21. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  22. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  23. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  24. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  25. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  26. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  27. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  28. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  29. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  30. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  31. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  32. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  33. Jun 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  34. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  35. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  36. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  37. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  38. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  39. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  40. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  41. Jul 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  42. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  43. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  44. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  45. Nov 2018 — Mar 2019 [monthly]

    Recruiting PHASE1

  46. Aug 2018 — Nov 2018 [monthly]

    Recruiting PHASE1

  47. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE1

  48. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  49. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE1

  50. Dec 2017 — Mar 2018 [monthly]

    Recruiting PHASE1

  51. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  52. Oct 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • BioNTech SE
  • Genentech, Inc.
Data source: Genentech, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Amsterdam, Netherlands , Aurora, United States , Barcelona, Spain , Boston, United States , Ghent, Belgium , Immenhausen, Germany , Las Vegas, United States , Liège, Belgium , London, United Kingdom , Nashville, United States and 14 more locations