deltatrials
Completed PHASE1/PHASE2 INTERVENTIONAL 2-arm NCT03418480

HARE-40: HPV Anti-CD40 RNA vaccinE (HARE-40)

Therapeutic HPV Vaccine (BNT113) Trial in HPV16 Driven Carcinoma

Sponsor: BioNTech SE

Conditions Cervical Neoplasm Head and Neck Neoplasm Human Papilloma Virus Related Carcinoma Penile Neoplasms Malignant Unknown Primary Tumors
Interventions BNT113
Updated 13 times since 2018 Last updated: Feb 6, 2024 Started: Apr 11, 2017 Primary completion: Nov 1, 2023 Completion: Jan 24, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE1/PHASE2 clinical study on Cervical Neoplasm and Head and Neck Neoplasm, this trial is completed. The trial is conducted by BioNTech SE and has accumulated 13 data snapshots since 2017. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2019 · 13 months · monthly snapshot~Jul 2019 – ~Apr 2020 · 9 months · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Jun 2022 · 12 months · monthly snapshot~Jun 2022 – ~Jun 2023 · 12 months · monthly snapshot~Jun 2023 – ~Oct 2023 · 4 months · monthly snapshot~Oct 2023 – ~Mar 2024 · 5 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 23 months · monthly snapshot

Change History

13 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE1/PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  3. Mar 2024 — Jul 2024 [monthly]

    Completed PHASE1_PHASE2

    Status: Active Not Recruiting → Completed

  4. Oct 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Suspended → Active Not Recruiting

  5. Jun 2023 — Oct 2023 [monthly]

    Suspended PHASE1_PHASE2

    Status: Recruiting → Suspended

▶ Show 8 earlier versions

  1. Jun 2022 — Jun 2023 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Active Not Recruiting → Recruiting

  2. Jun 2021 — Jun 2022 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Suspended → Active Not Recruiting

  3. Jan 2021 — Jun 2021 [monthly]

    Suspended PHASE1_PHASE2

  4. Aug 2020 — Jan 2021 [monthly]

    Suspended PHASE1_PHASE2

  5. Apr 2020 — Aug 2020 [monthly]

    Suspended PHASE1_PHASE2

    Status: Recruiting → Suspended

  6. Jul 2019 — Apr 2020 [monthly]

    Recruiting PHASE1_PHASE2

  7. Jun 2018 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  8. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Apr 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • BioNTech SE
  • University of Southampton
Data source: University of Southampton

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations