deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT03300544

Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer

A Phase I Study of Talimogene Laherparepvec (Talimogene Laherparepvec) With Neoadjuvant Chemotherapy and Radiation in Adenocarcinoma of the Rectum

Sponsor: National Cancer Institute (NCI)

Conditions Locally Advanced Rectal Adenocarcinoma Metastatic Rectal Adenocarcinoma Rectal Adenocarcinoma Stage III Rectal Cancer AJCC v7 Stage IIIA Rectal Cancer AJCC v7 Stage IIIB Rectal Cancer AJCC v7 Stage IIIC Rectal Cancer AJCC v7 Stage IV Rectal Cancer AJCC v7 Stage IVA Rectal Cancer AJCC v7 Stage IVB Rectal Cancer AJCC v7
Interventions Capecitabine Fluorouracil Leucovorin Oxaliplatin Radiation Therapy Talimogene Laherparepvec
Updated 32 times since 2017 Last updated: May 1, 2024 Started: May 14, 2019 Primary completion: Mar 22, 2022 Completion: Mar 22, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Inadequate accrual rate

Other terminated trials from National Cancer Institute (NCI)

See all terminations from National Cancer Institute (NCI)

A PHASE1 clinical study on Locally Advanced Rectal Adenocarcinoma and Metastatic Rectal Adenocarcinoma, this trial is terminated or withdrawn. The trial is conducted by National Cancer Institute (NCI) and has accumulated 32 data snapshots since 2019. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Oct 2017 – ~May 2018 · 7 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Feb 2019 · 6 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Oct 2019 · 3 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Oct 2020 · 4 months · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~May 2021 · 4 months · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Nov 2022 · 4 months · monthly snapshot~Nov 2022 – ~Jun 2024 · 19 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

32 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  3. Jun 2024 — Jul 2024 [monthly]

    Terminated PHASE1

    Status: Active Not Recruiting → Terminated

  4. Nov 2022 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jul 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE1

▶ Show 27 earlier versions

  1. Apr 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE1

  2. Feb 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  3. Nov 2021 — Feb 2022 [monthly]

    Recruiting PHASE1

  4. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  5. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  6. Jan 2021 — May 2021 [monthly]

    Recruiting PHASE1

  7. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  8. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  9. Jun 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  10. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  11. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  12. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  13. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  14. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1

  15. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  16. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  17. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  18. Jul 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  19. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  20. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  21. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE1

  22. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  23. Aug 2018 — Feb 2019 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  24. Jul 2018 — Aug 2018 [monthly]

    Suspended PHASE1

  25. Jun 2018 — Jul 2018 [monthly]

    Suspended PHASE1

  26. May 2018 — Jun 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  27. Oct 2017 — May 2018 [monthly]

    Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
Data source: National Cancer Institute (NCI)

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations