deltatrials
Terminated PHASE3 INTERVENTIONAL 2-arm NCT03302494

WAveCrest Vs. Watchman TranssEptal LAA Closure to REduce AF-Mediated STroke 2 (WAVECREST2)

WAveCrest Vs. Watchman TranssEptal LAA Closure to REduce AF-Mediated STroke 2. A Prospective, Multicenter, Randomized, Active Controlled, Clinical Trial of the Coherex WaveCrest® Left Atrial Appendage Occlusion System Compared to the Watchman® LAA Closure Device for the Reduction in Risk of Ischemic Stroke or Systemic Embolism in Subjects With Non-valvular Atrial Fibrillation That Have an Appropriate Rationale to Seek a Non-pharmacologic Alternative to Chronic Oral Anticoagulation.

Sponsor: Biosense Webster, Inc.

Conditions Stroke
Interventions Coherex WaveCrest® Left Atrial Appendage Occlusion System Watchman® LAA Closure Device
Updated 42 times since 2017 Last updated: Mar 5, 2025 Started: Dec 27, 2017 Primary completion: Dec 21, 2023 Completion: Dec 21, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Study closed due to device design modification

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A PHASE3 clinical study on Stroke, this trial is terminated or withdrawn. The trial is conducted by Biosense Webster, Inc. and has accumulated 42 data snapshots since 2017. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Oct 2017 – ~Feb 2018 · 4 months · monthly snapshot~Feb 2018 – ~Jun 2018 · 4 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Oct 2019 · 8 months · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~May 2020 · 4 months · monthly snapshot~May 2020 – ~Sep 2020 · 4 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Sep 2021 · 8 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Feb 2023 · 2 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Apr 2024 · 2 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~Sep 2025 · 5 months · monthly snapshot~Sep 2025 – present · 12 months · monthly snapshot

Change History

42 versions recorded

  1. Sep 2025 — Present [monthly]

    Terminated PHASE3

  2. Apr 2025 — Sep 2025 [monthly]

    Terminated PHASE3

  3. Jan 2025 — Apr 2025 [monthly]

    Terminated PHASE3

  4. Sep 2024 — Jan 2025 [monthly]

    Terminated PHASE3

  5. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE3

▶ Show 37 earlier versions

  1. Apr 2024 — Jul 2024 [monthly]

    Terminated PHASE3

    Status: Active Not Recruiting → Terminated

  2. Feb 2024 — Apr 2024 [monthly]

    Active Not Recruiting PHASE3

  3. Jan 2024 — Feb 2024 [monthly]

    Active Not Recruiting PHASE3

  4. Dec 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE3

  5. Nov 2023 — Dec 2023 [monthly]

    Active Not Recruiting PHASE3

  6. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE3

  7. Sep 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE3

  8. Aug 2023 — Sep 2023 [monthly]

    Active Not Recruiting PHASE3

  9. Jun 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE3

  10. May 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE3

  11. Apr 2023 — May 2023 [monthly]

    Active Not Recruiting PHASE3

  12. Mar 2023 — Apr 2023 [monthly]

    Active Not Recruiting PHASE3

  13. Feb 2023 — Mar 2023 [monthly]

    Active Not Recruiting PHASE3

  14. Dec 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE3

  15. Nov 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE3

  16. Sep 2022 — Nov 2022 [monthly]

    Active Not Recruiting PHASE3

  17. Jul 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE3

  18. Jun 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  19. May 2022 — Jun 2022 [monthly]

    Active Not Recruiting PHASE3

  20. Apr 2022 — May 2022 [monthly]

    Active Not Recruiting PHASE3

  21. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  22. Feb 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE3

  23. Jan 2022 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  24. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE3

  25. Nov 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  26. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  27. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  28. Jan 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  29. Sep 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  30. May 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

    Status: Active Not Recruiting → Recruiting

  31. Jan 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  32. Oct 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  33. Feb 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  34. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE3

  35. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  36. Feb 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  37. Oct 2017 — Feb 2018 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Biosense Webster, Inc.
  • Coherex Medical
Data source: Coherex Medical

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Atlanta, United States , Austin, United States , Baltimore, United States , Bay Shore, United States , Birmingham, United States , Chandler, United States , Columbus, United States , Fort Worth, United States , Harrisburg, United States , Jacksonville, United States and 13 more locations