deltatrials
Completed PHASE1 INTERVENTIONAL 11-arm NCT03307785

Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042

Phase 1b Dose-Finding Study of Niraparib, TSR-022, Bevacizumab, and Platinum-Based Doublet Chemotherapy in Combination With TSR-042 in Patients With Advanced or Metastatic Cancer

Sponsor: Tesaro, Inc.

Conditions Advanced Cancer Metastatic Cancer Neoplasms Non Small Cell Lung Cancer Non Small Cell Lung Cancer Metastatic Non Small Cell Lung Cancer Stage IIIB Solid Tumor
Interventions Bevacizumab Carboplatin-Nab-Paclitaxel Carboplatin-Paclitaxel Carboplatin-Pemetrexed Niraparib TSR-022 TSR-042
Updated 30 times since 2017 Last updated: Nov 10, 2025 Started: Oct 12, 2017 Primary completion: Feb 26, 2020 Completion: Dec 11, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates Advanced Cancer and Metastatic Cancer and is currently completed. Tesaro, Inc. leads this study, which shows 30 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Oct 2017 – ~Nov 2017 · 31 days · monthly snapshot~Nov 2017 – ~Jan 2018 · 2 months · monthly snapshot~Jan 2018 – ~Jun 2018 · 5 months · monthly snapshot~Jun 2018 – ~Dec 2018 · 6 months · monthly snapshot~Dec 2018 – ~Apr 2019 · 4 months · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Oct 2019 · 4 months · monthly snapshot~Oct 2019 – ~Jan 2020 · 3 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Aug 2020 · 2 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Jun 2021 · 5 months · monthly snapshot~Jun 2021 – ~Dec 2021 · 6 months · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Mar 2022 · 59 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~Sep 2022 · 5 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~Jul 2023 · 7 months · monthly snapshot~Jul 2023 – ~Jan 2024 · 6 months · monthly snapshot~Jan 2024 – ~Mar 2024 · 2 months · monthly snapshot~Mar 2024 – ~Jun 2024 · 3 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2025 · 14 months · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – present · 7 months · monthly snapshot

Change History

30 versions recorded

  1. Dec 2025 — Present [monthly]

    Completed PHASE1

  2. Nov 2025 — Dec 2025 [monthly]

    Completed PHASE1

    Status: Active Not Recruiting → Completed

  3. Sep 2024 — Nov 2025 [monthly]

    Active Not Recruiting PHASE1

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1

  5. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1

▶ Show 25 earlier versions

  1. Mar 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1

  2. Jan 2024 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1

  3. Jul 2023 — Jan 2024 [monthly]

    Active Not Recruiting PHASE1

  4. Dec 2022 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1

  5. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE1

  6. Apr 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE1

  7. Mar 2022 — Apr 2022 [monthly]

    Active Not Recruiting PHASE1

  8. Jan 2022 — Mar 2022 [monthly]

    Active Not Recruiting PHASE1

  9. Dec 2021 — Jan 2022 [monthly]

    Active Not Recruiting PHASE1

  10. Jun 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE1

  11. Jan 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE1

  12. Oct 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE1

  13. Aug 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE1

  14. Jun 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE1

  15. May 2020 — Jun 2020 [monthly]

    Active Not Recruiting PHASE1

  16. Feb 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE1

  17. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  18. Oct 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

  19. Jun 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  20. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  21. Dec 2018 — Apr 2019 [monthly]

    Recruiting PHASE1

  22. Jun 2018 — Dec 2018 [monthly]

    Recruiting PHASE1

  23. Jan 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

  24. Nov 2017 — Jan 2018 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  25. Oct 2017 — Nov 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Tesaro, Inc.
Data source: Tesaro, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations