deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 2-arm NCT03323463

Major De-escalation to 30 Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma

A Prospective Single Arm Non-inferiority Trial of Major Radiation Dose De-Escalation Concurrent With Chemotherapy for Human Papilloma Virus Associated Oropharyngeal Carcinoma (Major De-escalation to 30Gy for Select Human Papillomavirus Associated Oropharyngeal Carcinoma)

Sponsor: Memorial Sloan Kettering Cancer Center

Conditions HPV-Associated Oropharyngeal Squamous Cell Carcinoma Squamous Cell Carcinoma of the Neck
Interventions 30 Gy over 3 weeks 5Fluorouracil Carboplatin Cisplatin F-FMISO PET/CT Scan Proton Therapy
Updated 37 times since 2017 Last updated: Jan 23, 2026 Started: Oct 16, 2017 Primary completion: Oct 31, 2026 Completion: Oct 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE2 trial investigates HPV-Associated Oropharyngeal Squamous Cell Carcinoma and Squamous Cell Carcinoma of the Neck and is currently ongoing. Memorial Sloan Kettering Cancer Center leads this study, which shows 37 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Nov 2017 – ~Dec 2017 · 30 days · monthly snapshot~Dec 2017 – ~Jun 2018 · 6 months · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Jan 2019 · 4 months · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Dec 2020 · 4 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Nov 2021 · 2 months · monthly snapshot~Nov 2021 – ~Feb 2022 · 3 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Sep 2022 · 3 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Aug 2023 · 4 months · monthly snapshot~Aug 2023 – ~Feb 2024 · 6 months · monthly snapshot~Feb 2024 – ~May 2024 · 3 months · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~Feb 2026 · 12 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

37 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  5. May 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 32 earlier versions

  1. Feb 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Aug 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Apr 2023 — Aug 2023 [monthly]

    Recruiting PHASE2

  4. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2

  5. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE2

  6. Nov 2022 — Feb 2023 [monthly]

    Recruiting PHASE2

  7. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE2

  8. Jun 2022 — Sep 2022 [monthly]

    Recruiting PHASE2

  9. Feb 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  10. Nov 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  11. Sep 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  12. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  13. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  14. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  15. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  16. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  17. Aug 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  18. May 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  19. Feb 2020 — May 2020 [monthly]

    Recruiting PHASE2

  20. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE2

  21. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  22. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  23. Jul 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  24. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  25. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  26. Mar 2019 — May 2019 [monthly]

    Recruiting PHASE2

  27. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  28. Sep 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  29. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE2

  30. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  31. Dec 2017 — Jun 2018 [monthly]

    Recruiting PHASE2

  32. Nov 2017 — Dec 2017 [monthly]

    Recruiting PHASE2

    First recorded

Oct 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Memorial Sloan Kettering Cancer Center
Data source: Memorial Sloan Kettering Cancer Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations