deltatrials
Terminated PHASE2 INTERVENTIONAL 2-arm NCT03334409

Pazopanib Hydrochloride With or Without Ascorbic Acid in Treating Patients With Kidney Cancer That Is Metastatic or Cannot Be Removed by Surgery

Randomized, Phase II Trial of Intravenous Ascorbic Acid (Vitamin C) as an Adjunct to Pazopanib in the First-Line or Post-Immunotherapy Setting for Metastatic or Unresectable Clear Cell Renal Cell Carcinoma (ccRCC)

Sponsor: Academic and Community Cancer Research United

Conditions Clear Cell Renal Cell Carcinoma Metastatic Clear Cell Renal Cell Carcinoma Stage III Renal Cell Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v7 Unresectable Renal Cell Carcinoma
Interventions Ascorbic Acid Pazopanib Hydrochloride
Updated 18 times since 2017 Last updated: Mar 18, 2022 Started: Feb 16, 2018 Primary completion: Mar 13, 2021 Completion: Mar 13, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Due to loss of funding from the private foundation source

Other terminated trials from Academic and Community Cancer Research United

See all terminations from Academic and Community Cancer Research United

Other Clear Cell Renal Cell Carcinoma trials with similar outcome

Browse all Clear Cell Renal Cell Carcinoma trials

Listed as NCT03334409, this PHASE2 trial focuses on Clear Cell Renal Cell Carcinoma and Metastatic Clear Cell Renal Cell Carcinoma and remains terminated or withdrawn. Sponsored by Academic and Community Cancer Research United, it has been updated 18 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2017 – ~May 2018 · 5 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Aug 2018 · 2 months · monthly snapshot~Aug 2018 – ~Feb 2019 · 6 months · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~Sep 2019 · 5 months · monthly snapshot~Sep 2019 – ~Nov 2019 · 2 months · monthly snapshot~Nov 2019 – ~Nov 2020 · 12 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Apr 2022 · 10 months · monthly snapshot~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 22 months · monthly snapshot

Change History

18 versions recorded

  1. Sep 2024 — Present [monthly]

    Terminated PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  3. Apr 2022 — Jul 2024 [monthly]

    Terminated PHASE2

  4. Jun 2021 — Apr 2022 [monthly]

    Terminated PHASE2

    Status: Active Not Recruiting → Terminated

  5. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

▶ Show 13 earlier versions

  1. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  2. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  3. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE2

  4. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  5. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  6. Nov 2019 — Nov 2020 [monthly]

    Recruiting PHASE2

  7. Sep 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  8. Apr 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  9. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  10. Aug 2018 — Feb 2019 [monthly]

    Recruiting PHASE2

  11. Jun 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  12. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  13. Dec 2017 — May 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Academic and Community Cancer Research United
  • National Cancer Institute (NCI)
Data source: Academic and Community Cancer Research United

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations