deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 4-arm NCT03344965

Olaparib In Metastatic Breast Cancer

A Phase 2 Study of Olaparib Monotherapy in Metastatic Breast Cancer Patients With Germline or Somatic Mutations in DNA Repair Genes (Olaparib Expanded)

Sponsor: AstraZeneca

Conditions ATM Gene Mutation BRIP1 Gene Mutation CHEK2 Gene Mutation Invasive Breast Cancer Metastatic Breast Cancer NBN Gene Mutation PALB2 Gene Mutation RAD51 Gene Mutation Somatic Mutation Breast Cancer (BRCA1) Somatic Mutation Breast Cancer (BRCA2)
Interventions Olaparib
Updated 29 times since 2017 Last updated: Dec 31, 2025 Started: Apr 1, 2018 Primary completion: Jul 30, 2025 Completion: Jun 30, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on ATM Gene Mutation and BRIP1 Gene Mutation, this trial is ongoing. The trial is conducted by AstraZeneca and has accumulated 29 data snapshots since 2018. Oncology trials at this stage typically focus on safety, tolerability, and early efficacy signals.

Status Flow

~Dec 2017 – ~Apr 2018 · 4 months · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Oct 2018 · 4 months · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Jul 2019 · 4 months · monthly snapshot~Jul 2019 – ~Sep 2019 · 2 months · monthly snapshot~Sep 2019 – ~Feb 2020 · 5 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Sep 2020 · 5 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Sep 2021 · 4 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Apr 2022 · 6 months · monthly snapshot~Apr 2022 – ~Jul 2022 · 3 months · monthly snapshot~Jul 2022 – ~Jul 2023 · 12 months · monthly snapshot~Jul 2023 – ~Mar 2024 · 8 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Apr 2025 · 5 months · monthly snapshot~Apr 2025 – ~Jun 2025 · 2 months · monthly snapshot~Jun 2025 – ~Sep 2025 · 3 months · monthly snapshot~Sep 2025 – ~Feb 2026 · 5 months · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

29 versions recorded

  1. Feb 2026 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Sep 2025 — Feb 2026 [monthly]

    Active Not Recruiting PHASE2

  3. Jun 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Apr 2025 — Jun 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Nov 2024 — Apr 2025 [monthly]

    Active Not Recruiting PHASE2

▶ Show 24 earlier versions

  1. Sep 2024 — Nov 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Mar 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Jul 2023 — Mar 2024 [monthly]

    Recruiting PHASE2

  5. Jul 2022 — Jul 2023 [monthly]

    Recruiting PHASE2

  6. Apr 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  7. Oct 2021 — Apr 2022 [monthly]

    Recruiting PHASE2

  8. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  9. May 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  10. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE2

  11. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  12. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  13. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Active Not Recruiting → Recruiting

  14. Apr 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2

  15. Feb 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  16. Sep 2019 — Feb 2020 [monthly]

    Recruiting PHASE2

  17. Jul 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  18. Mar 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  19. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  20. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

  21. Oct 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  22. Jun 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  23. Apr 2018 — Jun 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  24. Dec 2017 — Apr 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
  • Beth Israel Deaconess Medical Center
  • Dana-Farber Cancer Institute
  • Johns Hopkins University
Data source: Beth Israel Deaconess Medical Center

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Baltimore, United States , Basking Ridge, United States , Birmingham, United States , Boston, United States , Chicago, United States , Commack, United States , Durham, United States , East White Plains, United States , Erie, United States , Indianapolis, United States and 8 more locations