deltatrials
Completed PHASE3 INTERVENTIONAL 6-arm NCT03345836

A Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Biologic Therapy

Sponsor: AbbVie

Conditions Crohn's Disease
Interventions Matching Placebo for Upadacitinib Upadacitinib
Updated 41 times since 2017 Last updated: Jul 18, 2022 Started: Nov 29, 2017 Primary completion: Aug 11, 2021 Completion: Aug 11, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03345836, this PHASE3 trial focuses on Crohn's Disease and remains completed. Sponsored by AbbVie, it has been updated 41 times since 2017, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Feb 2018 · 31 days · monthly snapshot~Feb 2018 – ~Mar 2018 · 28 days · monthly snapshot~Mar 2018 – ~May 2018 · 2 months · monthly snapshot~May 2018 – ~Jun 2018 · 31 days · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Dec 2019 · 2 months · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jun 2020 · 2 months · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Dec 2020 · 2 months · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~May 2021 · 2 months · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Sep 2022 · 11 months · monthly snapshot~Sep 2022 – ~Jul 2024 · 22 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

41 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  4. Sep 2022 — Jul 2024 [monthly]

    Completed PHASE3

  5. Oct 2021 — Sep 2022 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

▶ Show 36 earlier versions

  1. Jun 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

  2. May 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  3. Mar 2021 — May 2021 [monthly]

    Recruiting PHASE3

  4. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE3

  5. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  6. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  7. Oct 2020 — Dec 2020 [monthly]

    Recruiting PHASE3

  8. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE3

  9. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE3

  10. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE3

  11. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE3

  12. Apr 2020 — Jun 2020 [monthly]

    Recruiting PHASE3

  13. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE3

  14. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE3

  15. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE3

  16. Oct 2019 — Dec 2019 [monthly]

    Recruiting PHASE3

  17. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  18. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  19. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  20. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  21. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  22. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  23. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  24. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  25. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  26. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  27. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  28. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

  29. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE3

  30. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE3

  31. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE3

  32. May 2018 — Jun 2018 [monthly]

    Recruiting PHASE3

  33. Mar 2018 — May 2018 [monthly]

    Recruiting PHASE3

  34. Feb 2018 — Mar 2018 [monthly]

    Recruiting PHASE3

  35. Jan 2018 — Feb 2018 [monthly]

    Recruiting PHASE3

  36. Dec 2017 — Jan 2018 [monthly]

    Recruiting PHASE3

    First recorded

Nov 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AbbVie
Data source: AbbVie

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Adelaide, Australia , Alexandria, Egypt , Alingsås, Sweden , Almada, Portugal , Alor Star, Malaysia , Amiens, France , Amsterdam, Netherlands , Ankara, Turkey (Türkiye) , Ann Arbor, United States and 337 more locations