deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT03403634

Celecoxib, Recombinant Interferon Alfa-2b, and Rintatolimod in Treating Patients With Colorectal Cancer Metastatic to the Liver

Phase 2a Study Evaluating a Chemokine-Modulatory Regimen in Patients With Colorectal Cancer Metastatic to the Liver

Sponsor: National Cancer Institute (NCI)

Conditions Metastatic Carcinoma in the Liver Recurrent Colorectal Carcinoma Stage IV Colorectal Cancer AJCC v7 Stage IVA Colorectal Cancer AJCC v7 Stage IVB Colorectal Cancer AJCC v7
Interventions Celecoxib Laboratory Biomarker Analysis Recombinant Interferon Alfa-2b Rintatolimod
Updated 26 times since 2018 Last updated: Feb 25, 2022 Started: Apr 19, 2018 Primary completion: Dec 23, 2020 Completion: Aug 29, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03403634, this PHASE2 trial focuses on Metastatic Carcinoma in the Liver and Recurrent Colorectal Carcinoma and remains completed. Sponsored by National Cancer Institute (NCI), it has been updated 26 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Feb 2018 – ~Apr 2018 · 59 days · monthly snapshot~Apr 2018 – ~Jun 2018 · 2 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Dec 2018 · 5 months · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Aug 2019 · 2 months · monthly snapshot~Aug 2019 – ~Oct 2019 · 2 months · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Sep 2020 · 3 months · monthly snapshot~Sep 2020 – ~Jan 2021 · 4 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Jun 2021 · 3 months · monthly snapshot~Jun 2021 – ~Nov 2021 · 5 months · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshot~Apr 2022 – ~Jul 2024 · 27 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – present · 24 months · monthly snapshot

Change History

26 versions recorded

  1. Sep 2024 — Present [monthly]

    Completed PHASE2

  2. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  3. Apr 2022 — Jul 2024 [monthly]

    Completed PHASE2

  4. Nov 2021 — Apr 2022 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

  5. Jun 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE2

▶ Show 21 earlier versions

  1. Mar 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Sep 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  5. Jun 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  6. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2

  7. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE2

  8. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE2

  9. Nov 2019 — Jan 2020 [monthly]

    Recruiting PHASE2

  10. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  11. Aug 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  12. Jun 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

    Phase: EARLY_PHASE1 → PHASE2

  13. May 2019 — Jun 2019 [monthly]

    Recruiting EARLY_PHASE1

  14. Mar 2019 — May 2019 [monthly]

    Recruiting EARLY_PHASE1

  15. Feb 2019 — Mar 2019 [monthly]

    Recruiting EARLY_PHASE1

  16. Jan 2019 — Feb 2019 [monthly]

    Recruiting EARLY_PHASE1

  17. Dec 2018 — Jan 2019 [monthly]

    Recruiting EARLY_PHASE1

  18. Jul 2018 — Dec 2018 [monthly]

    Recruiting EARLY_PHASE1

  19. Jun 2018 — Jul 2018 [monthly]

    Recruiting EARLY_PHASE1

  20. Apr 2018 — Jun 2018 [monthly]

    Recruiting EARLY_PHASE1

    Status: Not Yet Recruiting → Recruiting

  21. Feb 2018 — Apr 2018 [monthly]

    Not Yet Recruiting EARLY_PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • National Cancer Institute (NCI)
  • Roswell Park Cancer Institute
Data source: Roswell Park Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations