deltatrials
Recruiting PHASE1/PHASE2 INTERVENTIONAL 19-arm NCT03424005

A Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic or Locally Advanced Breast Cancer (Morpheus-panBC)

A Phase Ib/II, Open-label, Multicenter, Randomized Umbrella Study Evaluating the Efficacy and Safety of Multiple Treatment Combinations in Patients With Metastatic Breast Cancer (Morpheus-panBC)

Sponsor: Gilead Sciences

Conditions Metastatic Breast Cancer
Interventions Abemaciclib Atezolizumab Atirmociclib Bevacizumab Capecitabine Chemotherapy (Gemcitabine + Carboplatin or Eribulin) Empagliflozin Fulvestrant Inavolisib Inavolisib (Dose #1) Inavolisib (Dose #2) Ipatasertib Letrozole Metformin Nab-Paclitaxel Palbociclib Ribociclib (Dose #1) Ribociclib (Dose #2) SGN-LIV1A Sacituzumab Govitecan Selicrelumab Tocilizumab Trastuzumab Deruxtecan
Updated 73 times since 2018 Last updated: Feb 12, 2026 Started: Mar 30, 2018 Primary completion: Sep 30, 2030 Completion: Sep 30, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Metastatic Breast Cancer and is currently actively recruiting participants. Gilead Sciences leads this study, which shows 73 recorded versions since 2018 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Sep 2018 · 31 days · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Dec 2018 · 2 months · monthly snapshot~Dec 2018 – ~Feb 2019 · 2 months · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~May 2020 · 2 months · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Apr 2022 · 59 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Oct 2022 · 30 days · monthly snapshot~Oct 2022 – ~Nov 2022 · 31 days · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Mar 2023 · 3 months · monthly snapshot~Mar 2023 – ~Jun 2023 · 3 months · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Dec 2025 · 3 months · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

73 versions recorded

  1. Feb 2026 — Present [monthly]

    Recruiting PHASE1/PHASE2

  2. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE1/PHASE2

  3. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE1/PHASE2

  4. Sep 2025 — Dec 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Aug 2025 — Sep 2025 [monthly]

    Recruiting PHASE1/PHASE2

▶ Show 68 earlier versions

  1. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE1/PHASE2

  2. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE1/PHASE2

  3. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE1/PHASE2

  6. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1/PHASE2

  7. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE1/PHASE2

  8. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE1/PHASE2

  9. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE1/PHASE2

  10. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE1/PHASE2

  11. Sep 2024 — Oct 2024 [monthly]

    Recruiting PHASE1/PHASE2

  12. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1/PHASE2

  13. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  14. Apr 2024 — Jul 2024 [monthly]

    Recruiting PHASE1_PHASE2

  15. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE1_PHASE2

  16. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1_PHASE2

  17. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE1_PHASE2

  18. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE1_PHASE2

  19. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE1_PHASE2

  20. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Active Not Recruiting → Recruiting

  21. Jul 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  22. Jun 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  23. Mar 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  24. Dec 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  25. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1_PHASE2

  26. Oct 2022 — Nov 2022 [monthly]

    Recruiting PHASE1_PHASE2

  27. Sep 2022 — Oct 2022 [monthly]

    Recruiting PHASE1_PHASE2

  28. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1_PHASE2

  29. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1_PHASE2

  30. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1_PHASE2

  31. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1_PHASE2

  32. Feb 2022 — Apr 2022 [monthly]

    Recruiting PHASE1_PHASE2

  33. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1_PHASE2

  34. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1_PHASE2

  35. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1_PHASE2

  36. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1_PHASE2

  37. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

  38. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1_PHASE2

  39. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1_PHASE2

  40. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1_PHASE2

  41. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1_PHASE2

  42. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1_PHASE2

  43. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  44. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  45. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  46. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  47. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1_PHASE2

  48. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1_PHASE2

  49. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  50. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

  51. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1_PHASE2

  52. Mar 2020 — May 2020 [monthly]

    Recruiting PHASE1_PHASE2

  53. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1_PHASE2

  54. Jan 2020 — Feb 2020 [monthly]

    Recruiting PHASE1_PHASE2

  55. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE1_PHASE2

  56. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1_PHASE2

  57. Jul 2019 — Nov 2019 [monthly]

    Recruiting PHASE1_PHASE2

  58. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE1_PHASE2

  59. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1_PHASE2

  60. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1_PHASE2

  61. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1_PHASE2

  62. Dec 2018 — Feb 2019 [monthly]

    Recruiting PHASE1_PHASE2

  63. Oct 2018 — Dec 2018 [monthly]

    Recruiting PHASE1_PHASE2

  64. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE1_PHASE2

  65. Aug 2018 — Sep 2018 [monthly]

    Recruiting PHASE1_PHASE2

  66. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE1_PHASE2

  67. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE1_PHASE2

  68. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1_PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Gilead Sciences
  • Hoffmann-La Roche
  • Pfizer
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Barcelona, Spain , Chattanooga, United States , Duarte, United States , Erlangen, Germany , Essen, Germany , Germantown, United States , Glasgow, United Kingdom , Goyang-si, South Korea , Hackensack, United States , Haifa, Israel and 27 more locations