deltatrials
Completed PHASE4 INTERVENTIONAL 4-arm NCT03453840

Extended Duration Artemether-lumefantrine Treatment for Malaria in Children (EXALT)

Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Conditions Uncomplicated Plasmodium Falciparum Malaria
Interventions Artemether-lumefantrine
Updated 13 times since 2018 Last updated: Apr 4, 2025 Started: Feb 21, 2018 Primary completion: Aug 31, 2021 Completion: Aug 31, 2021
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Uncomplicated Plasmodium Falciparum Malaria and is currently completed. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) leads this study, which shows 13 recorded versions since 2018 — indicating substantial longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Sep 2019 · 12 months · monthly snapshot~Sep 2019 – ~Aug 2020 · 11 months · monthly snapshot~Aug 2020 – ~Jan 2021 · 5 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Nov 2022 · 14 months · monthly snapshot~Nov 2022 – ~Jul 2024 · 20 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Feb 2025 · 5 months · monthly snapshot~Feb 2025 – ~May 2025 · 3 months · monthly snapshot~May 2025 – present · 14 months · monthly snapshot

Change History

13 versions recorded

  1. May 2025 — Present [monthly]

    Completed PHASE4

  2. Feb 2025 — May 2025 [monthly]

    Completed PHASE4

  3. Sep 2024 — Feb 2025 [monthly]

    Completed PHASE4

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE4

  5. Nov 2022 — Jul 2024 [monthly]

    Completed PHASE4

▶ Show 8 earlier versions

  1. Sep 2021 — Nov 2022 [monthly]

    Completed PHASE4

    Status: Active Not Recruiting → Completed

  2. Mar 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE4

  3. Jan 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE4

  4. Aug 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE4

    Status: Recruiting → Active Not Recruiting

  5. Sep 2019 — Aug 2020 [monthly]

    Recruiting PHASE4

  6. Sep 2018 — Sep 2019 [monthly]

    Recruiting PHASE4

  7. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE4

  8. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE4

    First recorded

Feb 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
  • Infectious Diseases Research Collaboration, Uganda
  • University of California, San Francisco
  • Yale University
Data source: University of California, San Francisco

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations