deltatrials
Recruiting PHASE3 INTERVENTIONAL 3-arm NCT05951595

A Study to Find Out if a Combination of 3 Medicines for the Treatment of Malaria Works as Well and is as Safe and Tolerable as Combinations of 2 Medicines (FD-TACT)

An Open-label, Randomised, Controlled, Non-inferiority Trial to Compare the Efficacy, Safety and Tolerability of a Fixed Dose Triple Artemisinin-based Combination Therapy (TACT) Artemether-lumefantrine-amodiaquine Versus First-line Artemisinin-based Combination Therapies (ACTs) for the Treatment of Uncomplicated Plasmodium Falciparum Malaria

Sponsor: University of Oxford

Updated 5 times since 2023 Last updated: Nov 14, 2025 Started: Sep 11, 2025 Primary completion: Jul 31, 2026 Completion: Jul 31, 2026
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Uncomplicated Plasmodium Falciparum Malaria and is currently actively recruiting participants. University of Oxford leads this study, which shows 5 recorded versions since 2025 — indicating limited longitudinal coverage. Longitudinal tracking of infectious disease trials helps identify durability of treatment effects.

Status Flow

~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshotNot Yet Recruiting~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jul 2025 · 10 months · monthly snapshotNot Yet Recruiting~Jul 2025 – ~Dec 2025 · 5 months · monthly snapshotUnknown~Dec 2025 – present · 7 months · monthly snapshotRecruiting

Change History

5 versions recorded
  1. Dec 2025 — Present [monthly]

    Recruiting PHASE3

    Status: UnknownRecruiting

  2. Jul 2025 — Dec 2025 [monthly]

    Unknown PHASE3

    Status: Not Yet RecruitingUnknown

  3. Sep 2024 — Jul 2025 [monthly]

    Not Yet Recruiting PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Not Yet Recruiting PHASE3

  5. Aug 2023 — Jul 2024 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • University of Oxford
Data source: University of Oxford

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations