A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471
An Open-Label Phase 2 Proof-of-Concept Study in Patients With C3 Glomerulopathy (C3G) or Immune-Complex Membranoproliferative Glomerulonephritis (IC-MPGN) Treated With ACH-0144471
Sponsor: Alexion Pharmaceuticals, Inc.
Terminated
The reason for terminating study early was inconclusive efficacy results. No safety findings were identified.
Other terminated trials from Alexion Pharmaceuticals, Inc.
- Immunoglobulin A Nephropathy · Phase PHASE2 · Aug 2025
- Geographic Atrophy · Phase PHASE2 · Jan 2025
- IgAN · Phase PHASE2 · Dec 2024
- Neurofibromatosis Type 1 · Nov 2024
- Healthy · Phase PHASE1 · Aug 2024
More terminations from Alexion Pharmaceuticals, Inc.
Listed as NCT03459443, this PHASE2 trial focuses on C3 Glomerulonephritis and C3 Glomerulopathy and remains terminated or withdrawn. Sponsored by Alexion Pharmaceuticals, Inc., it has been updated 19 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.
Status Flow
Change History
19 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE2
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Sep 2024 — Sep 2025 [monthly]
Terminated PHASE2
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE2
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Dec 2023 — Jul 2024 [monthly]
Terminated PHASE2
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Sep 2023 — Dec 2023 [monthly]
Terminated PHASE2
▶ Show 14 earlier versions
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Apr 2023 — Sep 2023 [monthly]
Terminated PHASE2
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Sep 2022 — Apr 2023 [monthly]
Terminated PHASE2
Status: Completed → Terminated
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Apr 2022 — Sep 2022 [monthly]
Completed PHASE2
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Nov 2021 — Apr 2022 [monthly]
Completed PHASE2
Status: Active Not Recruiting → Completed
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Jan 2021 — Nov 2021 [monthly]
Active Not Recruiting PHASE2
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Jun 2020 — Jan 2021 [monthly]
Active Not Recruiting PHASE2
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May 2020 — Jun 2020 [monthly]
Active Not Recruiting PHASE2
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Oct 2019 — May 2020 [monthly]
Active Not Recruiting PHASE2
Status: Recruiting → Active Not Recruiting
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Feb 2019 — Oct 2019 [monthly]
Recruiting PHASE2
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Sep 2018 — Feb 2019 [monthly]
Recruiting PHASE2
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Aug 2018 — Sep 2018 [monthly]
Recruiting PHASE2
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Jul 2018 — Aug 2018 [monthly]
Recruiting PHASE2
-
Jun 2018 — Jul 2018 [monthly]
Recruiting PHASE2
Status: Not Yet Recruiting → Recruiting
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Mar 2018 — Jun 2018 [monthly]
Not Yet Recruiting PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Alexion Pharmaceuticals, Inc.
For direct contact, visit the study record on ClinicalTrials.gov .