Completed PHASE4 INTERVENTIONAL 2-arm NCT03463317

Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation Compared to Medical Therapy (CLOSURE-AF)

Left Atrial Appendage CLOSURE in Patients With Atrial Fibrillation at High Risk of Stroke and Bleeding Compared to Medical Therapy: a Prospective Randomized Clinical Trial

Sponsor: Atrial Fibrillation Network

Conditions Atrial Fibrillation

Interventions Acetylsalicylic acid Apixaban CE-mark approved LAA closure devices Clopidogrel Dabigatran Edoxaban Phenprocoumon Rivaroxaban Warfarin

Updated 10 times since 2018 Last updated: Dec 6, 2025 Started: Feb 28, 2018 Primary completion: Nov 30, 2024 Completion: Nov 30, 2024

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE4 trial investigates Atrial Fibrillation and is currently completed. Atrial Fibrillation Network leads this study, which shows 10 recorded versions since 2018 — indicating substantial longitudinal coverage. Heart and vascular conditions benefit from the kind of long-term tracking this trial provides.

Status Flow

Change History

10 versions recorded

Jan 2026 — Present [monthly]

Completed PHASE4
Oct 2025 — Jan 2026 [monthly]

Completed PHASE4
Apr 2025 — Oct 2025 [monthly]

Completed PHASE4

Status: Recruiting → Completed
Sep 2024 — Apr 2025 [monthly]

Recruiting PHASE4
Jul 2024 — Sep 2024 [monthly]

Recruiting PHASE4

▶ Show 5 earlier versions

Sep 2021 — Jul 2024 [monthly]

Recruiting PHASE4
Jan 2021 — Sep 2021 [monthly]

Recruiting PHASE4
Feb 2020 — Jan 2021 [monthly]

Recruiting PHASE4
Jun 2018 — Feb 2020 [monthly]

Recruiting PHASE4
Mar 2018 — Jun 2018 [monthly]

Recruiting PHASE4

First recorded

Feb 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

Atrial Fibrillation Network
Charite University, Berlin, Germany
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
Stiftung Institut fuer Herzinfarktforschung

Data source: Charite University, Berlin, Germany

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Berlin, Germany , Brandenburg, Germany , Bremen, Germany , Coburg, Germany , Dachau, Germany , Dresden, Germany , Erfurt, Germany , Frankfurt, Germany , Freiburg im Breisgau, Germany , Greifswald, Germany and 18 more locations