Completed PHASE3 INTERVENTIONAL 2-arm NCT03470545

Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy (EXPLORER-HCM)

A Randomized, Double Blind, Placebo Controlled Clinical Study to Evaluate Mavacamten (MYK-461) in Adults With Symptomatic Obstructive Hypertrophic Cardiomyopathy

Sponsor: MyoKardia, Inc.

Conditions Obstructive Hypertrophic Cardiomyopathy

Interventions Placebo mavacamten

Updated 23 times since 2018 Last updated: Sep 7, 2021 Started: May 29, 2018 Primary completion: Mar 14, 2020 Completion: May 6, 2020

This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE3 clinical study on Obstructive Hypertrophic Cardiomyopathy, this trial is completed. The trial is conducted by MyoKardia, Inc. and has accumulated 23 data snapshots since 2018. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

Change History

23 versions recorded

Sep 2025 — Present [monthly]

Completed PHASE3
Sep 2024 — Sep 2025 [monthly]

Completed PHASE3
Jul 2024 — Sep 2024 [monthly]

Completed PHASE3
Nov 2021 — Jul 2024 [monthly]

Completed PHASE3
Jan 2021 — Nov 2021 [monthly]

Completed PHASE3

▶ Show 18 earlier versions

Dec 2020 — Jan 2021 [monthly]

Completed PHASE3
Nov 2020 — Dec 2020 [monthly]

Completed PHASE3
Sep 2020 — Nov 2020 [monthly]

Completed PHASE3
Jun 2020 — Sep 2020 [monthly]

Completed PHASE3

Status: Active Not Recruiting → Completed
May 2020 — Jun 2020 [monthly]

Active Not Recruiting PHASE3
Feb 2020 — May 2020 [monthly]

Active Not Recruiting PHASE3
Dec 2019 — Feb 2020 [monthly]

Active Not Recruiting PHASE3
Oct 2019 — Dec 2019 [monthly]

Active Not Recruiting PHASE3

Status: Recruiting → Active Not Recruiting
Aug 2019 — Oct 2019 [monthly]

Recruiting PHASE3
Jul 2019 — Aug 2019 [monthly]

Recruiting PHASE3
Feb 2019 — Jul 2019 [monthly]

Recruiting PHASE3
Dec 2018 — Feb 2019 [monthly]

Recruiting PHASE3
Nov 2018 — Dec 2018 [monthly]

Recruiting PHASE3
Sep 2018 — Nov 2018 [monthly]

Recruiting PHASE3
Aug 2018 — Sep 2018 [monthly]

Recruiting PHASE3
Jul 2018 — Aug 2018 [monthly]

Recruiting PHASE3

Status: Not Yet Recruiting → Recruiting
Jun 2018 — Jul 2018 [monthly]

Not Yet Recruiting PHASE3
Apr 2018 — Jun 2018 [monthly]

Not Yet Recruiting PHASE3

First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:

MyoKardia, Inc.

Data source: MyoKardia, Inc.

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

A Coruña, Spain , Aalst, Belgium , Aarhus N, Denmark , Almada, Portugal , Ann Arbor, United States , Ashkelon, Israel , Bad Nauheim, Germany , Berlin, Germany , Bethlehem, United States , Boston, United States and 54 more locations