deltatrials
Terminated PHASE2 INTERVENTIONAL 1-arm NCT03514017

Ibrutinib and PD-1 Blockade in High Risk Lymphocytic Leukemia

Phase II Trial of Ibrutinib and PD-1 Blockade in High Risk Chronic Lymphocytic Leukemia to Improve Immune Dysfunction

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Conditions Chronic Lymphocytic Leukemia
Interventions Ibrutinib Pembrolizumab
Updated 29 times since 2018 Last updated: Feb 26, 2026 Started: May 31, 2019 Primary completion: May 16, 2023 Completion: May 16, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Funding unavailable

Other terminated trials from H. Lee Moffitt Cancer Center and Research Institute

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Other Chronic Lymphocytic Leukemia trials with similar outcome

Browse all Chronic Lymphocytic Leukemia trials

This PHASE2 trial investigates Chronic Lymphocytic Leukemia and is currently terminated or withdrawn. H. Lee Moffitt Cancer Center and Research Institute leads this study, which shows 29 recorded versions since 2019 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Dec 2018 · 5 months · monthly snapshot~Dec 2018 – ~Mar 2019 · 3 months · monthly snapshot~Mar 2019 – ~May 2019 · 2 months · monthly snapshot~May 2019 – ~Oct 2019 · 5 months · monthly snapshot~Oct 2019 – ~Mar 2020 · 5 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Feb 2022 · 5 months · monthly snapshot~Feb 2022 – ~Jun 2022 · 4 months · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Dec 2022 · 5 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Oct 2023 · 4 months · monthly snapshot~Oct 2023 – ~Mar 2024 · 5 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Mar 2025 · 3 months · monthly snapshot~Mar 2025 – ~Jun 2025 · 3 months · monthly snapshot~Jun 2025 – ~Oct 2025 · 4 months · monthly snapshot~Oct 2025 – ~Jan 2026 · 3 months · monthly snapshot~Jan 2026 – ~Mar 2026 · 59 days · monthly snapshot~Mar 2026 – present · 2 months · monthly snapshot

Change History

29 versions recorded

  1. Mar 2026 — Present [monthly]

    Terminated PHASE2

  2. Jan 2026 — Mar 2026 [monthly]

    Terminated PHASE2

  3. Oct 2025 — Jan 2026 [monthly]

    Terminated PHASE2

  4. Jun 2025 — Oct 2025 [monthly]

    Terminated PHASE2

  5. Mar 2025 — Jun 2025 [monthly]

    Terminated PHASE2

▶ Show 24 earlier versions

  1. Dec 2024 — Mar 2025 [monthly]

    Terminated PHASE2

  2. Sep 2024 — Dec 2024 [monthly]

    Terminated PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE2

  4. Mar 2024 — Jul 2024 [monthly]

    Terminated PHASE2

  5. Oct 2023 — Mar 2024 [monthly]

    Terminated PHASE2

  6. Jun 2023 — Oct 2023 [monthly]

    Terminated PHASE2

    Status: Suspended → Terminated

  7. May 2023 — Jun 2023 [monthly]

    Suspended PHASE2

  8. Dec 2022 — May 2023 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  9. Jul 2022 — Dec 2022 [monthly]

    Recruiting PHASE2

  10. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE2

  11. Feb 2022 — Jun 2022 [monthly]

    Recruiting PHASE2

  12. Sep 2021 — Feb 2022 [monthly]

    Recruiting PHASE2

  13. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  14. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  15. Nov 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  16. Aug 2020 — Nov 2020 [monthly]

    Suspended PHASE2

  17. Apr 2020 — Aug 2020 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  18. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  19. Oct 2019 — Mar 2020 [monthly]

    Recruiting PHASE2

  20. May 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  21. Mar 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE2

  22. Dec 2018 — Mar 2019 [monthly]

    Not Yet Recruiting PHASE2

  23. Jul 2018 — Dec 2018 [monthly]

    Not Yet Recruiting PHASE2

  24. Jun 2018 — Jul 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lee Moffitt Cancer Center and Research Institute
  • Janssen Scientific Affairs, LLC
  • Merck Sharp & Dohme LLC
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations