deltatrials
Terminated PHASE1 INTERVENTIONAL 1-arm NCT03760523

Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia

Phase 1/1b Dose Escalation Study of Minnelide in Relapsed or Refractory Acute Myeloid Leukemia

Sponsor: H. Lee Moffitt Cancer Center and Research Institute

Conditions Acute Myeloid Leukemia
Interventions Minnelide
Updated 26 times since 2018 Last updated: Jan 5, 2026 Started: Apr 18, 2019 Primary completion: Oct 9, 2023 Completion: Oct 9, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Terminated

Toxicity -Two DLT events occurred

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Listed as NCT03760523, this PHASE1 trial focuses on Acute Myeloid Leukemia and remains terminated or withdrawn. Sponsored by H. Lee Moffitt Cancer Center and Research Institute, it has been updated 26 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Dec 2018 – ~Apr 2019 · 4 months · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Oct 2019 · 5 months · monthly snapshot~Oct 2019 – ~Mar 2020 · 5 months · monthly snapshot~Mar 2020 – ~Aug 2020 · 5 months · monthly snapshot~Aug 2020 – ~Oct 2020 · 2 months · monthly snapshot~Oct 2020 – ~Jan 2021 · 3 months · monthly snapshot~Jan 2021 – ~Mar 2021 · 59 days · monthly snapshot~Mar 2021 – ~Sep 2021 · 6 months · monthly snapshot~Sep 2021 – ~Jan 2022 · 4 months · monthly snapshot~Jan 2022 – ~Jun 2022 · 5 months · monthly snapshot~Jun 2022 – ~Nov 2022 · 5 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Oct 2023 · 2 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Mar 2024 · 4 months · monthly snapshot~Mar 2024 – ~Jul 2024 · 4 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Apr 2025 · 3 months · monthly snapshot~Apr 2025 – ~Jul 2025 · 3 months · monthly snapshot~Jul 2025 – ~Oct 2025 · 3 months · monthly snapshot~Oct 2025 – ~Feb 2026 · 4 months · monthly snapshot~Feb 2026 – present · 7 months · monthly snapshot

Change History

26 versions recorded

  1. Feb 2026 — Present [monthly]

    Terminated PHASE1

  2. Oct 2025 — Feb 2026 [monthly]

    Terminated PHASE1

  3. Jul 2025 — Oct 2025 [monthly]

    Terminated PHASE1

  4. Apr 2025 — Jul 2025 [monthly]

    Terminated PHASE1

  5. Jan 2025 — Apr 2025 [monthly]

    Terminated PHASE1

▶ Show 21 earlier versions

  1. Sep 2024 — Jan 2025 [monthly]

    Terminated PHASE1

  2. Jul 2024 — Sep 2024 [monthly]

    Terminated PHASE1

  3. Mar 2024 — Jul 2024 [monthly]

    Terminated PHASE1

  4. Nov 2023 — Mar 2024 [monthly]

    Terminated PHASE1

    Status: Recruiting → Terminated

  5. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

  6. Aug 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  7. May 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  8. Dec 2022 — May 2023 [monthly]

    Recruiting PHASE1

  9. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1

  10. Jun 2022 — Nov 2022 [monthly]

    Recruiting PHASE1

  11. Jan 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  12. Sep 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  13. Mar 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  14. Jan 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  15. Oct 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  16. Aug 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

  17. Mar 2020 — Aug 2020 [monthly]

    Recruiting PHASE1

  18. Oct 2019 — Mar 2020 [monthly]

    Recruiting PHASE1

  19. May 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  20. Apr 2019 — May 2019 [monthly]

    Not Yet Recruiting PHASE1

  21. Dec 2018 — Apr 2019 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • H. Lee Moffitt Cancer Center and Research Institute
  • Minneamrita Therapeutics LLC
Data source: H. Lee Moffitt Cancer Center and Research Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations