deltatrials
Completed PHASE2 INTERVENTIONAL 1-arm NCT03522298

Safety, Pharmacokinetics and Efficacy of Paxalisib (GDC-0084) in Newly-diagnosed Glioblastoma

A Phase 2 Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of the PI3K/mTOR Inhibitor Paxalisib (GDC-0084) Administered to Patients With Glioblastoma Characterized by Unmethylated O6-methylguanine-methyltransferase Promoter Status Following Surgical Resection and Standard Concomitant Chemoradiation Therapy With Temozolomide

Sponsor: Kazia Therapeutics Limited

Updated 15 times since 2018 Last updated: Mar 5, 2025 Started: May 15, 2018 Primary completion: Mar 30, 2023 Completion: Mar 30, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

A PHASE2 clinical study on Glioblastoma, Adult, this trial is completed. The trial is conducted by Kazia Therapeutics Limited and has accumulated 15 data snapshots since 2018. Longitudinal tracking of this trial contributes to a broader understanding of treatment development timelines.

Status Flow

~Jun 2018 – ~Jul 2018 · 30 days · monthly snapshot~Jul 2018 – ~Aug 2018 · 31 days · monthly snapshot~Aug 2018 – ~Oct 2018 · 2 months · monthly snapshot~Oct 2018 – ~Mar 2020 · 17 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~Jul 2020 · 3 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Oct 2021 · 9 months · monthly snapshot~Oct 2021 – ~Sep 2022 · 11 months · monthly snapshot~Sep 2022 – ~Apr 2023 · 7 months · monthly snapshot~Apr 2023 – ~Apr 2024 · 12 months · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Apr 2025 · 7 months · monthly snapshot~Apr 2025 – present · 17 months · monthly snapshot

Change History

15 versions recorded
  1. Apr 2025 — Present [monthly]

    Completed PHASE2

  2. Sep 2024 — Apr 2025 [monthly]

    Completed PHASE2

  3. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  4. Apr 2024 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not RecruitingCompleted

  5. Apr 2023 — Apr 2024 [monthly]

    Active Not Recruiting PHASE2

Show 10 earlier versions
  1. Sep 2022 — Apr 2023 [monthly]

    Active Not Recruiting PHASE2

  2. Oct 2021 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

  3. Jan 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE2

  4. Jul 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2

  5. Apr 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2

    Status: RecruitingActive Not Recruiting

  6. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  7. Oct 2018 — Mar 2020 [monthly]

    Recruiting PHASE2

  8. Aug 2018 — Oct 2018 [monthly]

    Recruiting PHASE2

  9. Jul 2018 — Aug 2018 [monthly]

    Recruiting PHASE2

  10. Jun 2018 — Jul 2018 [monthly]

    Recruiting PHASE2

    First recorded

May 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Kazia Therapeutics Limited
Data source: Kazia Therapeutics Limited

For direct contact, visit the study record on ClinicalTrials.gov .