deltatrials
Completed OBSERVATIONAL NCT03545126

Human CNS Tau Kinetics in Tauopathies (TANGLES)

Sponsor: Association of Frontotemporal Degeneration

Interventions 13C6 Leucine
Updated 12 times since 2018 Last updated: Apr 12, 2022 Started: Aug 21, 2017 Primary completion: Mar 4, 2022 Completion: Mar 4, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03545126, this observational or N/A phase trial focuses on Corticobasal Degeneration (CBD) and Frontotemporal Dementia (FTD MAPT Mutation) and remains completed. Sponsored by Association of Frontotemporal Degeneration, it has been updated 12 times since 2017, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshotEnrolling By Invitation~Sep 2018 – ~Oct 2019 · 13 months · monthly snapshotRecruiting~Oct 2019 – ~Nov 2020 · 13 months · monthly snapshotRecruiting~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshotRecruiting~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshotRecruiting~Jan 2021 – ~Dec 2021 · 11 months · monthly snapshotRecruiting~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshotRecruiting~Jan 2022 – ~May 2022 · 4 months · monthly snapshotActive Not Recruiting~May 2022 – ~Jul 2024 · 26 months · monthly snapshotCompleted~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshotCompleted~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshotCompleted~Sep 2025 – present · 10 months · monthly snapshotCompleted

Change History

12 versions recorded
  1. Sep 2025 — Present [monthly]

    Completed

  2. Sep 2024 — Sep 2025 [monthly]

    Completed

  3. Jul 2024 — Sep 2024 [monthly]

    Completed

  4. May 2022 — Jul 2024 [monthly]

    Completed

    Status: Active Not RecruitingCompleted

  5. Jan 2022 — May 2022 [monthly]

    Active Not Recruiting

    Status: RecruitingActive Not Recruiting

Show 7 earlier versions
  1. Dec 2021 — Jan 2022 [monthly]

    Recruiting

  2. Jan 2021 — Dec 2021 [monthly]

    Recruiting

  3. Dec 2020 — Jan 2021 [monthly]

    Recruiting

  4. Nov 2020 — Dec 2020 [monthly]

    Recruiting

  5. Oct 2019 — Nov 2020 [monthly]

    Recruiting

  6. Sep 2018 — Oct 2019 [monthly]

    Recruiting

    Status: Enrolling By InvitationRecruiting

  7. Jul 2018 — Sep 2018 [monthly]

    Enrolling By Invitation

    First recorded

Aug 2017

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Association of Frontotemporal Degeneration
  • Tau Consortium
  • Washington University School of Medicine
Data source: Washington University School of Medicine

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations