deltatrials
Completed PHASE3 INTERVENTIONAL 1-arm NCT03557307

Study to Evaluate Efficacy and Safety of Benralizumab in Reducing Oral Corticosteroid Use in Adult Patients With Severe Asthma (PONENTE)

PONENTE: A Multicenter, Open-label, Phase 3b Efficacy and Safety Study of Benralizumab 30 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Patients With Severe Eosinophilic Asthma on High Dose Inhaled Corticosteroid Plus Long-acting β2 Agonist and Chronic Oral Corticosteroid Therapy

Sponsor: AstraZeneca

Conditions Asthma
Interventions Benralizumab
Updated 28 times since 2018 Last updated: May 9, 2023 Started: Aug 1, 2018 Primary completion: Apr 16, 2021 Completion: Mar 24, 2022
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Asthma and is currently completed. AstraZeneca leads this study, which shows 28 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~Jun 2019 · 2 months · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Nov 2019 · 4 months · monthly snapshot~Nov 2019 – ~Jan 2020 · 2 months · monthly snapshot~Jan 2020 – ~Feb 2020 · 31 days · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Aug 2020 · 3 months · monthly snapshot~Aug 2020 – ~Nov 2020 · 3 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Feb 2022 · 2 months · monthly snapshot~Feb 2022 – ~Jul 2022 · 5 months · monthly snapshot~Jul 2022 – ~Jul 2023 · 12 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Sep 2025 · 12 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – present · 10 months · monthly snapshot

Change History

28 versions recorded

  1. Nov 2025 — Present [monthly]

    Completed PHASE3

  2. Sep 2025 — Nov 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Sep 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 23 earlier versions

  1. Jul 2022 — Jul 2023 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  2. Feb 2022 — Jul 2022 [monthly]

    Active Not Recruiting PHASE3

  3. Dec 2021 — Feb 2022 [monthly]

    Active Not Recruiting PHASE3

  4. Sep 2021 — Dec 2021 [monthly]

    Active Not Recruiting PHASE3

  5. Jun 2021 — Sep 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Feb 2021 — Jun 2021 [monthly]

    Active Not Recruiting PHASE3

  7. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE3

  8. Nov 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE3

  9. Aug 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE3

  10. May 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE3

  11. Feb 2020 — May 2020 [monthly]

    Active Not Recruiting PHASE3

  12. Jan 2020 — Feb 2020 [monthly]

    Active Not Recruiting PHASE3

  13. Nov 2019 — Jan 2020 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  14. Jul 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  15. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  16. Apr 2019 — Jun 2019 [monthly]

    Recruiting PHASE3

  17. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  18. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  19. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  20. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  21. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

  22. Sep 2018 — Oct 2018 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  23. Jul 2018 — Sep 2018 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • AstraZeneca
Data source: AstraZeneca

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aalborg, Denmark , Ajax, Canada , Albany, United States , Angers, France , Ann Arbor, United States , Atlanta, United States , Aurora, United States , Bamberg, Germany , Barranquilla, Colombia , Berlin, Germany and 120 more locations