deltatrials
Completed INTERVENTIONAL NCT03570749

A Study of Baricitinib (LY3009104) in Participants With Severe or Very Severe Alopecia Areata (BRAVE-AA1)

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Operationally Seamless, Adaptive Phase 2/3 Study to Evaluate the Efficacy and Safety of Baricitinib in Adult Patients With Severe or Very Severe Alopecia Areata

Sponsor: Eli Lilly and Company

Updated 49 times since 2018 Last updated: Mar 30, 2026 Started: Sep 24, 2018 Primary completion: Feb 2, 2021 Completion: Jan 29, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03570749, this observational or N/A phase trial focuses on Alopecia Areata and remains completed. Sponsored by Eli Lilly and Company, it has been updated 49 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Jul 2018 – ~Sep 2018 · 2 months · monthly snapshot~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Jan 2020 · 31 days · monthly snapshot~Jan 2020 – ~Mar 2020 · 2 months · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2022 · 13 months · monthly snapshot~Apr 2022 – ~Mar 2023 · 11 months · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Jun 2023 · 2 months · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Nov 2023 · 2 months · monthly snapshot~Nov 2023 – ~Apr 2024 · 5 months · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Feb 2025 · 4 months · monthly snapshot~Feb 2025 – ~May 2025 · 3 months · monthly snapshot~May 2025 – ~Sep 2025 · 4 months · monthly snapshot~Sep 2025 – ~Nov 2025 · 2 months · monthly snapshot~Nov 2025 – ~Apr 2026 · 5 months · monthly snapshotApr 17, 2026 – present · 4 months · daily API

Change History

49 versions recorded
  1. Apr 17, 2026 — Present [daily]

    Completed

    Phase: PHASE2/PHASE3None

  2. Nov 2025 — Apr 2026 [monthly]

    Completed PHASE2/PHASE3

  3. Sep 2025 — Nov 2025 [monthly]

    Completed PHASE2/PHASE3

  4. May 2025 — Sep 2025 [monthly]

    Completed PHASE2/PHASE3

    Status: Active Not RecruitingCompleted

  5. Feb 2025 — May 2025 [monthly]

    Active Not Recruiting PHASE2/PHASE3

Show 44 earlier versions
  1. Oct 2024 — Feb 2025 [monthly]

    Active Not Recruiting PHASE2/PHASE3

  2. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE2/PHASE3

  3. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2/PHASE3

    Phase: PHASE2_PHASE3PHASE2/PHASE3

  4. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  5. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  6. Apr 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: RecruitingActive Not Recruiting

  7. Nov 2023 — Apr 2024 [monthly]

    Recruiting PHASE2_PHASE3

  8. Sep 2023 — Nov 2023 [monthly]

    Recruiting PHASE2_PHASE3

  9. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE2_PHASE3

  10. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Active Not RecruitingRecruiting

  11. Apr 2023 — Jun 2023 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: RecruitingActive Not Recruiting

  12. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Active Not RecruitingRecruiting

  13. Apr 2022 — Mar 2023 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  14. Mar 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  15. Feb 2021 — Mar 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  16. Jan 2021 — Feb 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  17. Dec 2020 — Jan 2021 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  18. Nov 2020 — Dec 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  19. Oct 2020 — Nov 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  20. Sep 2020 — Oct 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  21. Aug 2020 — Sep 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  22. Jul 2020 — Aug 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

  23. Jun 2020 — Jul 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: RecruitingActive Not Recruiting

  24. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE2_PHASE3

  25. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Active Not RecruitingRecruiting

  26. Mar 2020 — Apr 2020 [monthly]

    Active Not Recruiting PHASE2_PHASE3

    Status: RecruitingActive Not Recruiting

  27. Jan 2020 — Mar 2020 [monthly]

    Recruiting PHASE2_PHASE3

  28. Dec 2019 — Jan 2020 [monthly]

    Recruiting PHASE2_PHASE3

  29. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2_PHASE3

  30. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2_PHASE3

  31. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2_PHASE3

  32. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2_PHASE3

  33. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2_PHASE3

  34. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2_PHASE3

  35. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2_PHASE3

  36. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2_PHASE3

  37. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE2_PHASE3

  38. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE2_PHASE3

  39. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2_PHASE3

  40. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2_PHASE3

  41. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2_PHASE3

  42. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE2_PHASE3

    Status: Not Yet RecruitingRecruiting

  43. Sep 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

  44. Jul 2018 — Sep 2018 [monthly]

    Not Yet Recruiting PHASE2_PHASE3

    First recorded

Eligibility Summary

This study is designed to select up to two doses of baricitinib (referred to as low dose and high dose) and assess their efficacy and safety for the treatment of severe or very severe alopecia areata. An additional subpopulation of 60 participants in the US will enroll in the open-label addenda.

Contact Information

Sponsor contact:
  • Eli Lilly and Company
  • Incyte Corporation
Data source: ClinicalTrials.gov

For direct contact, visit the study record on ClinicalTrials.gov .