Volitinib in Treating Patients With Recurrent or Refractory Primary CNS Tumors
A Phase I Study of Savolitinib in Recurrent, Progressive or Refractory Medulloblastoma, High-Grade Glioma, Diffuse Intrinsic Pontine Glioma, and CNS Tumors Harboring MET Aberrations
Sponsor: National Cancer Institute (NCI)
Listed as NCT03598244, this PHASE1 trial focuses on Recurrent Diffuse Intrinsic Pontine Glioma and Recurrent Malignant Glioma and remains ongoing. Sponsored by National Cancer Institute (NCI), it has been updated 53 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
53 versions recorded-
Sep 2025 — Present [monthly]
Active Not Recruiting PHASE1
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May 2025 — Sep 2025 [monthly]
Active Not Recruiting PHASE1
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Apr 2025 — May 2025 [monthly]
Active Not Recruiting PHASE1
Status: Recruiting → Active Not Recruiting
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Mar 2025 — Apr 2025 [monthly]
Recruiting PHASE1
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Feb 2025 — Mar 2025 [monthly]
Recruiting PHASE1
▶ Show 48 earlier versions
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Dec 2024 — Feb 2025 [monthly]
Recruiting PHASE1
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Nov 2024 — Dec 2024 [monthly]
Recruiting PHASE1
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Oct 2024 — Nov 2024 [monthly]
Recruiting PHASE1
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Sep 2024 — Oct 2024 [monthly]
Recruiting PHASE1
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Jul 2024 — Sep 2024 [monthly]
Recruiting PHASE1
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Jun 2024 — Jul 2024 [monthly]
Recruiting PHASE1
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Apr 2024 — Jun 2024 [monthly]
Recruiting PHASE1
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Feb 2024 — Apr 2024 [monthly]
Recruiting PHASE1
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Jan 2024 — Feb 2024 [monthly]
Recruiting PHASE1
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Dec 2023 — Jan 2024 [monthly]
Recruiting PHASE1
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Nov 2023 — Dec 2023 [monthly]
Recruiting PHASE1
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Feb 2023 — Nov 2023 [monthly]
Recruiting PHASE1
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Jan 2023 — Feb 2023 [monthly]
Recruiting PHASE1
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Nov 2022 — Jan 2023 [monthly]
Recruiting PHASE1
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Sep 2022 — Nov 2022 [monthly]
Recruiting PHASE1
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Jul 2022 — Sep 2022 [monthly]
Recruiting PHASE1
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Jun 2022 — Jul 2022 [monthly]
Recruiting PHASE1
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Apr 2022 — Jun 2022 [monthly]
Recruiting PHASE1
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Jan 2022 — Apr 2022 [monthly]
Recruiting PHASE1
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Dec 2021 — Jan 2022 [monthly]
Recruiting PHASE1
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Oct 2021 — Dec 2021 [monthly]
Recruiting PHASE1
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Sep 2021 — Oct 2021 [monthly]
Recruiting PHASE1
Status: Suspended → Recruiting
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Apr 2021 — Sep 2021 [monthly]
Suspended PHASE1
Status: Recruiting → Suspended
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Feb 2021 — Apr 2021 [monthly]
Recruiting PHASE1
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Jan 2021 — Feb 2021 [monthly]
Recruiting PHASE1
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Dec 2020 — Jan 2021 [monthly]
Recruiting PHASE1
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Nov 2020 — Dec 2020 [monthly]
Recruiting PHASE1
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Oct 2020 — Nov 2020 [monthly]
Recruiting PHASE1
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Sep 2020 — Oct 2020 [monthly]
Recruiting PHASE1
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Jul 2020 — Sep 2020 [monthly]
Recruiting PHASE1
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Jun 2020 — Jul 2020 [monthly]
Recruiting PHASE1
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Apr 2020 — Jun 2020 [monthly]
Recruiting PHASE1
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Mar 2020 — Apr 2020 [monthly]
Recruiting PHASE1
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Feb 2020 — Mar 2020 [monthly]
Recruiting PHASE1
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Jan 2020 — Feb 2020 [monthly]
Recruiting PHASE1
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Dec 2019 — Jan 2020 [monthly]
Recruiting PHASE1
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Nov 2019 — Dec 2019 [monthly]
Recruiting PHASE1
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Oct 2019 — Nov 2019 [monthly]
Recruiting PHASE1
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Sep 2019 — Oct 2019 [monthly]
Recruiting PHASE1
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Aug 2019 — Sep 2019 [monthly]
Recruiting PHASE1
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Jul 2019 — Aug 2019 [monthly]
Recruiting PHASE1
Status: Suspended → Recruiting
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Jun 2019 — Jul 2019 [monthly]
Suspended PHASE1
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Mar 2019 — Jun 2019 [monthly]
Suspended PHASE1
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Feb 2019 — Mar 2019 [monthly]
Suspended PHASE1
Status: Recruiting → Suspended
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Jan 2019 — Feb 2019 [monthly]
Recruiting PHASE1
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Dec 2018 — Jan 2019 [monthly]
Recruiting PHASE1
Status: Not Yet Recruiting → Recruiting
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Oct 2018 — Dec 2018 [monthly]
Not Yet Recruiting PHASE1
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Aug 2018 — Oct 2018 [monthly]
Not Yet Recruiting PHASE1
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- National Cancer Institute (NCI)
For direct contact, visit the study record on ClinicalTrials.gov .