deltatrials
Active Not Recruiting PHASE2 INTERVENTIONAL 1-arm NCT03620669

1st Line Durvalumab in PS 2 NSCLC Patients

First Line Durvalumab in Patients With PD-L1 Positive, Advanced NSCLC With Performance Status 2 Unsuitable for Combination Chemotherapy. A Multicenter, Single-arm Phase II Trial

Sponsor: Swiss Cancer Institute

Conditions NSCLC Stage IIIB NSCLC Stage IV
Interventions Durvalumab
Updated 21 times since 2018 Last updated: Aug 14, 2025 Started: Dec 4, 2018 Primary completion: Jan 19, 2023 Completion: Sep 30, 2027
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03620669, this PHASE2 trial focuses on NSCLC Stage IIIB and NSCLC Stage IV and remains ongoing. Sponsored by Swiss Cancer Institute, it has been updated 21 times since 2018, reflecting substantial change activity. This study adds to the evidence base for this therapeutic area through structured, versioned documentation.

Status Flow

~Sep 2018 – ~Nov 2018 · 2 months · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Mar 2019 · 59 days · monthly snapshot~Mar 2019 – ~Oct 2019 · 7 months · monthly snapshot~Oct 2019 – ~Apr 2020 · 6 months · monthly snapshot~Apr 2020 – ~Jan 2021 · 9 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Dec 2021 · 3 months · monthly snapshot~Dec 2021 – ~Mar 2022 · 3 months · monthly snapshot~Mar 2022 – ~May 2022 · 2 months · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Feb 2023 · 5 months · monthly snapshot~Feb 2023 – ~Feb 2024 · 12 months · monthly snapshot~Feb 2024 – ~Jul 2024 · 5 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Mar 2025 · 6 months · monthly snapshot~Mar 2025 – ~Aug 2025 · 5 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

21 versions recorded

  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE2

  2. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE2

  3. Mar 2025 — Aug 2025 [monthly]

    Active Not Recruiting PHASE2

  4. Sep 2024 — Mar 2025 [monthly]

    Active Not Recruiting PHASE2

  5. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE2

▶ Show 16 earlier versions

  1. Feb 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE2

  2. Feb 2023 — Feb 2024 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2022 — Feb 2023 [monthly]

    Active Not Recruiting PHASE2

  4. May 2022 — Sep 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  5. Mar 2022 — May 2022 [monthly]

    Recruiting PHASE2

  6. Dec 2021 — Mar 2022 [monthly]

    Recruiting PHASE2

  7. Sep 2021 — Dec 2021 [monthly]

    Recruiting PHASE2

  8. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE2

  9. Jan 2021 — Apr 2021 [monthly]

    Recruiting PHASE2

  10. Apr 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

    Status: Suspended → Recruiting

  11. Oct 2019 — Apr 2020 [monthly]

    Suspended PHASE2

    Status: Recruiting → Suspended

  12. Mar 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  13. Jan 2019 — Mar 2019 [monthly]

    Recruiting PHASE2

  14. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE2

  15. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  16. Sep 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Swiss Cancer Institute
Data source: Swiss Cancer Institute

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aarau, Switzerland , Baden, Switzerland , Basel, Switzerland , Bellinzona, Switzerland , Bern, Switzerland , Chur, Switzerland , Fribourg, Switzerland , Geneva, Switzerland , Sankt Gallen, Switzerland , Thun, Switzerland and 1 more location