deltatrials
Completed PHASE3 INTERVENTIONAL 3-arm NCT03622593

A Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Participants With Diabetic Macular Edema (RHINE)

A Phase III, Multicenter, Randomized, Double-Masked, Active Comparator-Controlled Study to Evaluate the Efficacy and Safety of Faricimab (RO6867461) in Patients With Diabetic Macular Edema (RHINE)

Sponsor: Hoffmann-La Roche

Conditions Diabetic Macular Edema
Interventions Aflibercept Faricimab Sham Procedure
Updated 32 times since 2018 Last updated: Jul 2, 2025 Started: Oct 9, 2018 Primary completion: Oct 19, 2020 Completion: May 31, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Diabetic Macular Edema and is currently completed. Hoffmann-La Roche leads this study, which shows 32 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Dec 2018 · 30 days · monthly snapshot~Dec 2018 – ~Jan 2019 · 31 days · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jul 2019 · 2 months · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Feb 2020 · 3 months · monthly snapshot~Feb 2020 – ~May 2020 · 3 months · monthly snapshot~May 2020 – ~Jul 2020 · 2 months · monthly snapshot~Jul 2020 – ~Sep 2020 · 2 months · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Jan 2021 · 2 months · monthly snapshot~Jan 2021 – ~Apr 2021 · 3 months · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Apr 2022 · 5 months · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Sep 2022 · 4 months · monthly snapshot~Sep 2022 – ~Jul 2023 · 10 months · monthly snapshot~Jul 2023 – ~Jul 2024 · 12 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Aug 2025 · 11 months · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – present · 11 months · monthly snapshot

Change History

32 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Aug 2025 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Aug 2025 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jul 2023 — Jul 2024 [monthly]

    Completed PHASE3

▶ Show 27 earlier versions

  1. Sep 2022 — Jul 2023 [monthly]

    Completed PHASE3

  2. May 2022 — Sep 2022 [monthly]

    Completed PHASE3

  3. Apr 2022 — May 2022 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

  4. Nov 2021 — Apr 2022 [monthly]

    Active Not Recruiting PHASE3

  5. Oct 2021 — Nov 2021 [monthly]

    Active Not Recruiting PHASE3

  6. Sep 2021 — Oct 2021 [monthly]

    Active Not Recruiting PHASE3

    Status: Enrolling By Invitation → Active Not Recruiting

  7. Apr 2021 — Sep 2021 [monthly]

    Enrolling By Invitation PHASE3

  8. Jan 2021 — Apr 2021 [monthly]

    Enrolling By Invitation PHASE3

  9. Nov 2020 — Jan 2021 [monthly]

    Enrolling By Invitation PHASE3

  10. Sep 2020 — Nov 2020 [monthly]

    Enrolling By Invitation PHASE3

  11. Jul 2020 — Sep 2020 [monthly]

    Enrolling By Invitation PHASE3

  12. May 2020 — Jul 2020 [monthly]

    Enrolling By Invitation PHASE3

  13. Feb 2020 — May 2020 [monthly]

    Enrolling By Invitation PHASE3

  14. Nov 2019 — Feb 2020 [monthly]

    Enrolling By Invitation PHASE3

    Status: Recruiting → Enrolling By Invitation

  15. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE3

  16. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE3

  17. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE3

  18. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE3

  19. May 2019 — Jul 2019 [monthly]

    Recruiting PHASE3

  20. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE3

  21. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE3

  22. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE3

  23. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE3

  24. Dec 2018 — Jan 2019 [monthly]

    Recruiting PHASE3

  25. Nov 2018 — Dec 2018 [monthly]

    Recruiting PHASE3

  26. Oct 2018 — Nov 2018 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  27. Sep 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Aalborg, Denmark , Ankara, Turkey (Türkiye) , Aparecida de Goiânia, Brazil , Augusta, United States , Aurora, United States , Austin, United States , Bakersfield, United States , Baltimore, United States , Bangkok, Thailand , Barcelona, Spain and 146 more locations