deltatrials
Completed PHASE2 INTERVENTIONAL 2-arm NCT03644186

To Reduce the Use of Chemotherapy in Postmenopausal Patients With ER-positive and HER2-positive Breast Cancer (TOUCH) (TOUCH)

Phase II Open-label, Multicentre, Randomized Trial of Neoadjuvant Palbociclib in Combination With Hormonal Therapy and HER2 Blockade Versus Paclitaxel in Combination With HER2 Blockade for Postmenopausal Patients With Hormone Receptor Positive/HER2 Positive Early Breast Cancer

Sponsor: ETOP IBCSG Partners Foundation

Conditions Breast Cancer Estrogen Receptor Positive Tumor HER2-positive Breast Cancer
Interventions Letrozole Paclitaxel Palbociclib Pertuzumab Trastuzumab
Updated 32 times since 2018 Last updated: Dec 10, 2024 Started: Apr 16, 2019 Primary completion: Jan 3, 2023 Completion: Apr 14, 2023
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03644186, this PHASE2 trial focuses on Breast Cancer and Estrogen Receptor Positive Tumor and remains completed. Sponsored by ETOP IBCSG Partners Foundation, it has been updated 32 times since 2019, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Sep 2018 – ~Oct 2018 · 30 days · monthly snapshot~Oct 2018 – ~Jan 2019 · 3 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Apr 2019 · 59 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Apr 2020 · 2 months · monthly snapshot~Apr 2020 – ~Aug 2020 · 4 months · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Nov 2020 · 2 months · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Jun 2021 · 4 months · monthly snapshot~Jun 2021 – ~Oct 2021 · 4 months · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Sep 2022 · 10 months · monthly snapshot~Sep 2022 – ~Dec 2022 · 3 months · monthly snapshot~Dec 2022 – ~May 2023 · 5 months · monthly snapshot~May 2023 – ~Aug 2023 · 3 months · monthly snapshot~Aug 2023 – ~Jul 2024 · 11 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Jan 2025 · 4 months · monthly snapshot~Jan 2025 – ~Sep 2025 · 8 months · monthly snapshot~Sep 2025 – present · 8 months · monthly snapshot

Change History

32 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE2

  2. Jan 2025 — Sep 2025 [monthly]

    Completed PHASE2

  3. Sep 2024 — Jan 2025 [monthly]

    Completed PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE2

  5. Aug 2023 — Jul 2024 [monthly]

    Completed PHASE2

    Status: Active Not Recruiting → Completed

▶ Show 27 earlier versions

  1. May 2023 — Aug 2023 [monthly]

    Active Not Recruiting PHASE2

  2. Dec 2022 — May 2023 [monthly]

    Active Not Recruiting PHASE2

  3. Sep 2022 — Dec 2022 [monthly]

    Active Not Recruiting PHASE2

    Status: Recruiting → Active Not Recruiting

  4. Nov 2021 — Sep 2022 [monthly]

    Recruiting PHASE2

  5. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE2

  6. Jun 2021 — Oct 2021 [monthly]

    Recruiting PHASE2

  7. Feb 2021 — Jun 2021 [monthly]

    Recruiting PHASE2

  8. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE2

  9. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE2

  10. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE2

  11. Sep 2020 — Nov 2020 [monthly]

    Recruiting PHASE2

  12. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE2

  13. Apr 2020 — Aug 2020 [monthly]

    Recruiting PHASE2

  14. Feb 2020 — Apr 2020 [monthly]

    Recruiting PHASE2

  15. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE2

  16. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE2

  17. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE2

  18. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE2

  19. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE2

  20. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE2

  21. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE2

  22. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE2

  23. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE2

  24. Feb 2019 — Apr 2019 [monthly]

    Recruiting PHASE2

  25. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE2

    Status: Not Yet Recruiting → Recruiting

  26. Oct 2018 — Jan 2019 [monthly]

    Not Yet Recruiting PHASE2

  27. Sep 2018 — Oct 2018 [monthly]

    Not Yet Recruiting PHASE2

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • ETOP IBCSG Partners Foundation
  • Hoffmann-La Roche
  • Pfizer
Data source: ETOP IBCSG Partners Foundation

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Alessandria, Italy , Aviano, Italy , Avignon, France , Baden, Switzerland , Basel, Switzerland , Bellinzona, Switzerland , Bergamo, Italy , Bern, Switzerland , Bologna, Italy , Bolzano, Italy and 39 more locations