deltatrials
Completed PHASE3 INTERVENTIONAL 3-arm NCT03653832

Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial) (A2B)

Alpha 2 Agonists for Sedation to Produce Better Outcomes From Critical Illness (A2B Trial): A Randomised, Parallel-group, Allocation Concealed, Controlled, Open, Phase 3 Pragmatic Clinical and Cost- Effectiveness Trial With Internal Pilot

Sponsor: Edinburgh Napier University

Conditions Critical Illness
Interventions Clonidine Dexmedetomidine Propofol
Updated 17 times since 2018 Last updated: Oct 1, 2024 Started: Dec 10, 2018 Primary completion: Dec 14, 2023 Completion: Jul 31, 2024
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE3 trial investigates Critical Illness and is currently completed. Edinburgh Napier University leads this study, which shows 17 recorded versions since 2018 — indicating substantial longitudinal coverage. The change history captured here reflects the iterative nature of clinical trial conduct.

Status Flow

~Sep 2018 – ~Aug 2019 · 11 months · monthly snapshot~Aug 2019 – ~Jul 2020 · 11 months · monthly snapshot~Jul 2020 – ~Jan 2021 · 6 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Sep 2021 · 7 months · monthly snapshot~Sep 2021 – ~Apr 2022 · 7 months · monthly snapshot~Apr 2022 – ~Nov 2022 · 7 months · monthly snapshot~Nov 2022 – ~Feb 2023 · 3 months · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Sep 2023 · 6 months · monthly snapshot~Sep 2023 – ~Dec 2023 · 3 months · monthly snapshot~Dec 2023 – ~Jun 2024 · 6 months · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Nov 2024 · 2 months · monthly snapshot~Nov 2024 – ~Sep 2025 · 10 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

17 versions recorded

  1. Sep 2025 — Present [monthly]

    Completed PHASE3

  2. Nov 2024 — Sep 2025 [monthly]

    Completed PHASE3

  3. Sep 2024 — Nov 2024 [monthly]

    Completed PHASE3

  4. Jul 2024 — Sep 2024 [monthly]

    Completed PHASE3

  5. Jun 2024 — Jul 2024 [monthly]

    Completed PHASE3

    Status: Active Not Recruiting → Completed

▶ Show 12 earlier versions

  1. Dec 2023 — Jun 2024 [monthly]

    Active Not Recruiting PHASE3

    Status: Recruiting → Active Not Recruiting

  2. Sep 2023 — Dec 2023 [monthly]

    Recruiting PHASE3

  3. Mar 2023 — Sep 2023 [monthly]

    Recruiting PHASE3

  4. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE3

  5. Nov 2022 — Feb 2023 [monthly]

    Recruiting PHASE3

  6. Apr 2022 — Nov 2022 [monthly]

    Recruiting PHASE3

  7. Sep 2021 — Apr 2022 [monthly]

    Recruiting PHASE3

  8. Feb 2021 — Sep 2021 [monthly]

    Recruiting PHASE3

  9. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE3

  10. Jul 2020 — Jan 2021 [monthly]

    Recruiting PHASE3

  11. Aug 2019 — Jul 2020 [monthly]

    Recruiting PHASE3

    Status: Not Yet Recruiting → Recruiting

  12. Sep 2018 — Aug 2019 [monthly]

    Not Yet Recruiting PHASE3

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Edinburgh Napier University
  • Imperial College London
  • King's College London
  • NHS Lothian
  • Queen's University, Belfast
  • Royal Surrey County Hospital NHS Foundation Trust
  • The University of Queensland
  • University College, London
  • University Hospital of Wales
  • University of Cambridge
  • University of Edinburgh
  • University of Manchester
  • University of Warwick
  • West Hertfordshire Hospitals NHS Trust
Data source: University of Edinburgh

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Belfast, United Kingdom , Birmingham, United Kingdom , Blackpool, United Kingdom , Bristol, United Kingdom , Cambridge, United Kingdom , Cardiff, United Kingdom , Chester, United Kingdom , Dudley, United Kingdom , Dumfries, United Kingdom , Edinburgh, United Kingdom and 20 more locations