deltatrials
Active Not Recruiting PHASE1/PHASE2 INTERVENTIONAL 5-arm NCT03671018

A Study to Evaluate the Safety and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in B-Cell Non-Hodgkin Lymphoma

An Open-Label, Randomized, Multicenter, Phase Ib/II Trial Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of Mosunetuzumab (BTCT4465A) in Combination With Polatuzumab Vedotin in Patients With B-Cell Non-Hodgkin Lymphoma

Sponsor: Hoffmann-La Roche

Conditions B-cell Non-Hodgkin Lymphoma
Interventions Mosunetuzumab (IV) Mosunetuzumab (SC) Polatuzumab vedotin Rituximab Tocilizumab
Updated 61 times since 2018 Last updated: Nov 26, 2024 Started: Sep 25, 2018 Primary completion: Jan 30, 2024 Completion: Jul 20, 2025
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

Listed as NCT03671018, this PHASE1/PHASE2 trial focuses on B-cell Non-Hodgkin Lymphoma and remains ongoing. Sponsored by Hoffmann-La Roche, it has been updated 61 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.

Status Flow

~Oct 2018 – ~Nov 2018 · 31 days · monthly snapshot~Nov 2018 – ~Jan 2019 · 2 months · monthly snapshot~Jan 2019 – ~Feb 2019 · 31 days · monthly snapshot~Feb 2019 – ~Mar 2019 · 28 days · monthly snapshot~Mar 2019 – ~Apr 2019 · 31 days · monthly snapshot~Apr 2019 – ~May 2019 · 30 days · monthly snapshot~May 2019 – ~Jun 2019 · 31 days · monthly snapshot~Jun 2019 – ~Jul 2019 · 30 days · monthly snapshot~Jul 2019 – ~Aug 2019 · 31 days · monthly snapshot~Aug 2019 – ~Sep 2019 · 31 days · monthly snapshot~Sep 2019 – ~Oct 2019 · 30 days · monthly snapshot~Oct 2019 – ~Nov 2019 · 31 days · monthly snapshot~Nov 2019 – ~Dec 2019 · 30 days · monthly snapshot~Dec 2019 – ~Feb 2020 · 2 months · monthly snapshot~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~Jul 2023 · 3 months · monthly snapshot~Jul 2023 – ~Oct 2023 · 3 months · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Jan 2024 · 31 days · monthly snapshot~Jan 2024 – ~Feb 2024 · 31 days · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~Jul 2024 · 3 months · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Sep 2025 · 9 months · monthly snapshot~Sep 2025 – present · 10 months · monthly snapshot

Change History

61 versions recorded

  1. Sep 2025 — Present [monthly]

    Active Not Recruiting PHASE1/PHASE2

  2. Dec 2024 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  3. Sep 2024 — Dec 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  4. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  5. Apr 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

▶ Show 56 earlier versions

  1. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE1_PHASE2

  2. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1_PHASE2

  3. Jan 2024 — Feb 2024 [monthly]

    Recruiting PHASE1_PHASE2

  4. Dec 2023 — Jan 2024 [monthly]

    Recruiting PHASE1_PHASE2

  5. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE1_PHASE2

    Status: Active Not Recruiting → Recruiting

  6. Oct 2023 — Nov 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  7. Jul 2023 — Oct 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  8. Apr 2023 — Jul 2023 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting

  9. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1_PHASE2

  10. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

  11. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1_PHASE2

  12. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1_PHASE2

  13. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1_PHASE2

  14. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1_PHASE2

  15. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1_PHASE2

  16. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1_PHASE2

  17. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1_PHASE2

  18. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1_PHASE2

  19. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1_PHASE2

  20. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1_PHASE2

  21. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1_PHASE2

  22. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1_PHASE2

  23. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1_PHASE2

  24. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1_PHASE2

  25. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1_PHASE2

  26. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1_PHASE2

  27. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1_PHASE2

  28. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1_PHASE2

  29. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1_PHASE2

  30. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1_PHASE2

  31. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1_PHASE2

  32. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1_PHASE2

  33. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1_PHASE2

  34. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1_PHASE2

  35. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1_PHASE2

  36. Aug 2020 — Sep 2020 [monthly]

    Recruiting PHASE1_PHASE2

  37. Jul 2020 — Aug 2020 [monthly]

    Recruiting PHASE1_PHASE2

  38. Jun 2020 — Jul 2020 [monthly]

    Recruiting PHASE1_PHASE2

    Phase: PHASE1 → PHASE1_PHASE2

  39. May 2020 — Jun 2020 [monthly]

    Recruiting PHASE1

  40. Apr 2020 — May 2020 [monthly]

    Recruiting PHASE1

  41. Mar 2020 — Apr 2020 [monthly]

    Recruiting PHASE1

  42. Feb 2020 — Mar 2020 [monthly]

    Recruiting PHASE1

  43. Dec 2019 — Feb 2020 [monthly]

    Recruiting PHASE1

  44. Nov 2019 — Dec 2019 [monthly]

    Recruiting PHASE1

  45. Oct 2019 — Nov 2019 [monthly]

    Recruiting PHASE1

  46. Sep 2019 — Oct 2019 [monthly]

    Recruiting PHASE1

  47. Aug 2019 — Sep 2019 [monthly]

    Recruiting PHASE1

  48. Jul 2019 — Aug 2019 [monthly]

    Recruiting PHASE1

  49. Jun 2019 — Jul 2019 [monthly]

    Recruiting PHASE1

  50. May 2019 — Jun 2019 [monthly]

    Recruiting PHASE1

  51. Apr 2019 — May 2019 [monthly]

    Recruiting PHASE1

  52. Mar 2019 — Apr 2019 [monthly]

    Recruiting PHASE1

  53. Feb 2019 — Mar 2019 [monthly]

    Recruiting PHASE1

  54. Jan 2019 — Feb 2019 [monthly]

    Recruiting PHASE1

  55. Nov 2018 — Jan 2019 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting · Phase: PHASE1_PHASE2 → PHASE1

  56. Oct 2018 — Nov 2018 [monthly]

    Not Yet Recruiting PHASE1_PHASE2

    First recorded

Sep 2018

Trial started

Per CT.gov start date — pre-dates our first snapshot

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Aurora, United States , Barcelona, Spain , Birmingham, United States , Brussels, Belgium , Cambridge, United Kingdom , Charlotte, United States , Cáceres, Spain , Detroit, United States , Duarte, United States and 18 more locations