deltatrials
Recruiting PHASE1/PHASE2 INTERVENTIONAL 4-arm NCT04246086

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab + Lenalidomide (+Len), and the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Participants With Follicular Lymphoma

A Phase Ib/II, Open-Label, Multicenter Study With a Non-Randomized Stage Evaluating the Safety, Pharmacokinetics, and Efficacy of Mosunetuzumab Plus Lenalidomide (+Len), and a Randomized Stage Evaluating the Safety, Tolerability, and Pharmacokinetics of SC Versus IV Mosunetuzumab + Len in Patients With Follicular Lymphoma

Sponsor: Hoffmann-La Roche

Conditions Follicular Lymphoma
Interventions Lenalidomide Mosunetuzumab (IV) Mosunetuzumab (SC) Tocilizumab
Updated 65 times since 2020 Last updated: Feb 19, 2026 Started: Aug 12, 2020 Primary completion: Oct 15, 2030 Completion: Oct 15, 2030
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1/PHASE2 trial investigates Follicular Lymphoma and is currently actively recruiting participants. Hoffmann-La Roche leads this study, which shows 65 recorded versions since 2020 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Feb 2020 – ~Mar 2020 · 29 days · monthly snapshot~Mar 2020 – ~Apr 2020 · 31 days · monthly snapshot~Apr 2020 – ~May 2020 · 30 days · monthly snapshot~May 2020 – ~Jun 2020 · 31 days · monthly snapshot~Jun 2020 – ~Jul 2020 · 30 days · monthly snapshot~Jul 2020 – ~Aug 2020 · 31 days · monthly snapshot~Aug 2020 – ~Sep 2020 · 31 days · monthly snapshot~Sep 2020 – ~Oct 2020 · 30 days · monthly snapshot~Oct 2020 – ~Nov 2020 · 31 days · monthly snapshot~Nov 2020 – ~Dec 2020 · 30 days · monthly snapshot~Dec 2020 – ~Jan 2021 · 31 days · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Mar 2021 · 28 days · monthly snapshot~Mar 2021 – ~Apr 2021 · 31 days · monthly snapshot~Apr 2021 – ~May 2021 · 30 days · monthly snapshot~May 2021 – ~Jun 2021 · 31 days · monthly snapshot~Jun 2021 – ~Sep 2021 · 3 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Nov 2021 · 31 days · monthly snapshot~Nov 2021 – ~Dec 2021 · 30 days · monthly snapshot~Dec 2021 – ~Jan 2022 · 31 days · monthly snapshot~Jan 2022 – ~Feb 2022 · 31 days · monthly snapshot~Feb 2022 – ~Mar 2022 · 28 days · monthly snapshot~Mar 2022 – ~Apr 2022 · 31 days · monthly snapshot~Apr 2022 – ~May 2022 · 30 days · monthly snapshot~May 2022 – ~Jun 2022 · 31 days · monthly snapshot~Jun 2022 – ~Jul 2022 · 30 days · monthly snapshot~Jul 2022 – ~Sep 2022 · 2 months · monthly snapshot~Sep 2022 – ~Nov 2022 · 2 months · monthly snapshot~Nov 2022 – ~Dec 2022 · 30 days · monthly snapshot~Dec 2022 – ~Jan 2023 · 31 days · monthly snapshot~Jan 2023 – ~Feb 2023 · 31 days · monthly snapshot~Feb 2023 – ~Mar 2023 · 28 days · monthly snapshot~Mar 2023 – ~Apr 2023 · 31 days · monthly snapshot~Apr 2023 – ~May 2023 · 30 days · monthly snapshot~May 2023 – ~Jun 2023 · 31 days · monthly snapshot~Jun 2023 – ~Jul 2023 · 30 days · monthly snapshot~Jul 2023 – ~Aug 2023 · 31 days · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Nov 2023 · 31 days · monthly snapshot~Nov 2023 – ~Dec 2023 · 30 days · monthly snapshot~Dec 2023 – ~Mar 2024 · 3 months · monthly snapshot~Mar 2024 – ~May 2024 · 2 months · monthly snapshot~May 2024 – ~Jun 2024 · 31 days · monthly snapshot~Jun 2024 – ~Jul 2024 · 30 days · monthly snapshot~Jul 2024 – ~Sep 2024 · 2 months · monthly snapshot~Sep 2024 – ~Oct 2024 · 30 days · monthly snapshot~Oct 2024 – ~Nov 2024 · 31 days · monthly snapshot~Nov 2024 – ~Dec 2024 · 30 days · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Feb 2025 · 31 days · monthly snapshot~Feb 2025 – ~Mar 2025 · 28 days · monthly snapshot~Mar 2025 – ~Apr 2025 · 31 days · monthly snapshot~Apr 2025 – ~May 2025 · 30 days · monthly snapshot~May 2025 – ~Jun 2025 · 31 days · monthly snapshot~Jun 2025 – ~Jul 2025 · 30 days · monthly snapshot~Jul 2025 – ~Aug 2025 · 31 days · monthly snapshot~Aug 2025 – ~Sep 2025 · 31 days · monthly snapshot~Sep 2025 – ~Oct 2025 · 30 days · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – ~Dec 2025 · 30 days · monthly snapshot~Dec 2025 – ~Jan 2026 · 31 days · monthly snapshot~Jan 2026 – ~Feb 2026 · 31 days · monthly snapshot~Feb 2026 – present · 5 months · monthly snapshot

Change History

65 versions recorded

  1. Feb 2026 — Present [monthly]

    Recruiting PHASE1/PHASE2

  2. Jan 2026 — Feb 2026 [monthly]

    Recruiting PHASE1/PHASE2

  3. Dec 2025 — Jan 2026 [monthly]

    Recruiting PHASE1/PHASE2

  4. Nov 2025 — Dec 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE1/PHASE2

▶ Show 60 earlier versions

  1. Sep 2025 — Oct 2025 [monthly]

    Recruiting PHASE1/PHASE2

    Status: Active Not Recruiting → Recruiting

  2. Aug 2025 — Sep 2025 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Status: Recruiting → Active Not Recruiting

  3. Jul 2025 — Aug 2025 [monthly]

    Recruiting PHASE1/PHASE2

  4. Jun 2025 — Jul 2025 [monthly]

    Recruiting PHASE1/PHASE2

  5. May 2025 — Jun 2025 [monthly]

    Recruiting PHASE1/PHASE2

  6. Apr 2025 — May 2025 [monthly]

    Recruiting PHASE1/PHASE2

  7. Mar 2025 — Apr 2025 [monthly]

    Recruiting PHASE1/PHASE2

  8. Feb 2025 — Mar 2025 [monthly]

    Recruiting PHASE1/PHASE2

  9. Jan 2025 — Feb 2025 [monthly]

    Recruiting PHASE1/PHASE2

  10. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE1/PHASE2

  11. Nov 2024 — Dec 2024 [monthly]

    Recruiting PHASE1/PHASE2

  12. Oct 2024 — Nov 2024 [monthly]

    Recruiting PHASE1/PHASE2

    Status: Active Not Recruiting → Recruiting

  13. Sep 2024 — Oct 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

  14. Jul 2024 — Sep 2024 [monthly]

    Active Not Recruiting PHASE1/PHASE2

    Phase: PHASE1_PHASE2 → PHASE1/PHASE2

  15. Jun 2024 — Jul 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  16. May 2024 — Jun 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  17. Mar 2024 — May 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

  18. Dec 2023 — Mar 2024 [monthly]

    Active Not Recruiting PHASE1_PHASE2

    Status: Recruiting → Active Not Recruiting · Phase: PHASE1 → PHASE1_PHASE2

  19. Nov 2023 — Dec 2023 [monthly]

    Recruiting PHASE1

  20. Oct 2023 — Nov 2023 [monthly]

    Recruiting PHASE1

    Phase: PHASE1_PHASE2 → PHASE1

  21. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE1_PHASE2

  22. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE1_PHASE2

  23. Jul 2023 — Aug 2023 [monthly]

    Recruiting PHASE1_PHASE2

  24. Jun 2023 — Jul 2023 [monthly]

    Recruiting PHASE1_PHASE2

    Phase: PHASE1 → PHASE1_PHASE2

  25. May 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  26. Apr 2023 — May 2023 [monthly]

    Recruiting PHASE1

  27. Mar 2023 — Apr 2023 [monthly]

    Recruiting PHASE1

    Phase: PHASE1_PHASE2 → PHASE1

  28. Feb 2023 — Mar 2023 [monthly]

    Recruiting PHASE1_PHASE2

  29. Jan 2023 — Feb 2023 [monthly]

    Recruiting PHASE1_PHASE2

  30. Dec 2022 — Jan 2023 [monthly]

    Recruiting PHASE1_PHASE2

  31. Nov 2022 — Dec 2022 [monthly]

    Recruiting PHASE1_PHASE2

  32. Sep 2022 — Nov 2022 [monthly]

    Recruiting PHASE1_PHASE2

    Phase: PHASE1 → PHASE1_PHASE2

  33. Jul 2022 — Sep 2022 [monthly]

    Recruiting PHASE1

  34. Jun 2022 — Jul 2022 [monthly]

    Recruiting PHASE1

  35. May 2022 — Jun 2022 [monthly]

    Recruiting PHASE1

  36. Apr 2022 — May 2022 [monthly]

    Recruiting PHASE1

  37. Mar 2022 — Apr 2022 [monthly]

    Recruiting PHASE1

  38. Feb 2022 — Mar 2022 [monthly]

    Recruiting PHASE1

  39. Jan 2022 — Feb 2022 [monthly]

    Recruiting PHASE1

  40. Dec 2021 — Jan 2022 [monthly]

    Recruiting PHASE1

  41. Nov 2021 — Dec 2021 [monthly]

    Recruiting PHASE1

  42. Oct 2021 — Nov 2021 [monthly]

    Recruiting PHASE1

  43. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  44. Jun 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  45. May 2021 — Jun 2021 [monthly]

    Recruiting PHASE1

  46. Apr 2021 — May 2021 [monthly]

    Recruiting PHASE1

  47. Mar 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  48. Feb 2021 — Mar 2021 [monthly]

    Recruiting PHASE1

  49. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  50. Dec 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  51. Nov 2020 — Dec 2020 [monthly]

    Recruiting PHASE1

  52. Oct 2020 — Nov 2020 [monthly]

    Recruiting PHASE1

  53. Sep 2020 — Oct 2020 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  54. Aug 2020 — Sep 2020 [monthly]

    Not Yet Recruiting PHASE1

  55. Jul 2020 — Aug 2020 [monthly]

    Not Yet Recruiting PHASE1

  56. Jun 2020 — Jul 2020 [monthly]

    Not Yet Recruiting PHASE1

  57. May 2020 — Jun 2020 [monthly]

    Not Yet Recruiting PHASE1

  58. Apr 2020 — May 2020 [monthly]

    Not Yet Recruiting PHASE1

  59. Mar 2020 — Apr 2020 [monthly]

    Not Yet Recruiting PHASE1

  60. Feb 2020 — Mar 2020 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Hoffmann-La Roche
Data source: Hoffmann-La Roche

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations

Ann Arbor, United States , Barcelona, Spain , Baton Rouge, United States , Changchun, China , Changsha, China , Chattanooga, United States , Chengdu, China , Cleveland, United States , Duarte, United States , Durham, United States and 23 more locations