Intratumoral Cavrotolimod Combined With Pembrolizumab or Cemiplimab in Patients With Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors
Merkel Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, or Other Advanced Solid Tumors: A Phase 1b/2 Study of Cavrotolimod Combined With Pembrolizumab or Cemiplimab
Sponsor: Exicure, Inc.
Terminated
The study was canceled for administrative reasons.
Listed as NCT03684785, this PHASE1/PHASE2 trial focuses on Advanced or Metastatic Cutaneous Squamous Cell Carcinoma and Advanced or Metastatic Head and Neck Squamous Cell Carcinoma and remains terminated or withdrawn. Sponsored by Exicure, Inc., it has been updated 24 times since 2018, reflecting substantial change activity. This study contributes to the evolving evidence base for cancer treatment protocols.
Status Flow
Change History
24 versions recorded-
Sep 2025 — Present [monthly]
Terminated PHASE1/PHASE2
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Sep 2024 — Sep 2025 [monthly]
Terminated PHASE1/PHASE2
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Jul 2024 — Sep 2024 [monthly]
Terminated PHASE1/PHASE2
Phase: PHASE1_PHASE2 → PHASE1/PHASE2
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May 2022 — Jul 2024 [monthly]
Terminated PHASE1_PHASE2
Status: Active Not Recruiting → Terminated
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Jan 2022 — May 2022 [monthly]
Active Not Recruiting PHASE1_PHASE2
Status: Recruiting → Active Not Recruiting
▶ Show 19 earlier versions
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Nov 2021 — Jan 2022 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2021 — Nov 2021 [monthly]
Recruiting PHASE1_PHASE2
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Jun 2021 — Sep 2021 [monthly]
Recruiting PHASE1_PHASE2
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Feb 2021 — Jun 2021 [monthly]
Recruiting PHASE1_PHASE2
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Jan 2021 — Feb 2021 [monthly]
Recruiting PHASE1_PHASE2
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Nov 2020 — Jan 2021 [monthly]
Recruiting PHASE1_PHASE2
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Oct 2020 — Nov 2020 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2020 — Oct 2020 [monthly]
Recruiting PHASE1_PHASE2
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Apr 2020 — Sep 2020 [monthly]
Recruiting PHASE1_PHASE2
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Mar 2020 — Apr 2020 [monthly]
Recruiting PHASE1_PHASE2
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Feb 2020 — Mar 2020 [monthly]
Recruiting PHASE1_PHASE2
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Sep 2019 — Feb 2020 [monthly]
Recruiting PHASE1_PHASE2
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Jul 2019 — Sep 2019 [monthly]
Recruiting PHASE1_PHASE2
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Jun 2019 — Jul 2019 [monthly]
Recruiting PHASE1_PHASE2
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Apr 2019 — Jun 2019 [monthly]
Recruiting PHASE1_PHASE2
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Mar 2019 — Apr 2019 [monthly]
Recruiting PHASE1_PHASE2
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Feb 2019 — Mar 2019 [monthly]
Recruiting PHASE1_PHASE2
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Jan 2019 — Feb 2019 [monthly]
Recruiting PHASE1_PHASE2
Status: Not Yet Recruiting → Recruiting
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Oct 2018 — Jan 2019 [monthly]
Not Yet Recruiting PHASE1_PHASE2
First recorded
Eligibility Summary
No eligibility information available.
Contact Information
- Exicure, Inc.
For direct contact, visit the study record on ClinicalTrials.gov .