deltatrials
Recruiting PHASE1 INTERVENTIONAL 7-arm NCT03017820

A Vaccine (VSV-hIFNβ-NIS) With or Without Cyclophosphamide and Combinations of Ipilimumab, Nivolumab, and Cemiplimab in Treating Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia or Lymphoma

Phase I Trial of Systemic Administration of Vesicular Stomatitis Virus Genetically Engineered to Express NIS and Human Interferon, in Patients With Relapsed or Refractory Multiple Myeloma, Acute Myeloid Leukemia, Lymphomas, or Histiocytic/Dendritic Cell Neoplasms

Sponsor: Mayo Clinic

Conditions B-Cell Non-Hodgkin Lymphoma Histiocytic and Dendritic Cell Neoplasm Myelodysplastic Syndrome Previously Treated Myelodysplastic Syndrome Recurrent Adult Acute Myeloid Leukemia Recurrent Anaplastic Large Cell Lymphoma Recurrent Angioimmunoblastic T-Cell Lymphoma Recurrent Mycosis Fungoides Recurrent Plasma Cell Myeloma Recurrent Primary Cutaneous T-Cell Non-Hodgkin Lymphoma Recurrent T-Cell Non-Hodgkin Lymphoma Refractory Acute Myeloid Leukemia Refractory Anaplastic Large Cell Lymphoma Refractory Angioimmunoblastic T-Cell Lymphoma Refractory Mycosis Fungoides Refractory Peripheral T-Cell Lymphoma, Not Otherwise Specified Refractory Plasma Cell Myeloma Refractory Primary Cutaneous T-Cell Non-Hodgkin Lymphoma Refractory T-Cell Non-Hodgkin Lymphoma
Interventions Biopsy Procedure Biospecimen Collection Bone Marrow Aspiration Bone Marrow Biopsy Cemiplimab Computed Tomography Cyclophosphamide Echocardiography Test Multigated Acquisition Scan Nivolumab Positron Emission Tomography Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter Ruxolitinib Single Photon Emission Computed Tomography ipilimumab
Updated 35 times since 2017 Last updated: Oct 3, 2025 Started: Apr 4, 2017 Primary completion: Dec 31, 2028 Completion: Apr 1, 2032
This information is for research purposes only and is not medical advice. Consult a healthcare provider before making any medical decision.

This PHASE1 trial investigates B-Cell Non-Hodgkin Lymphoma and Histiocytic and Dendritic Cell Neoplasm and is currently actively recruiting participants. Mayo Clinic leads this study, which shows 35 recorded versions since 2017 — indicating substantial longitudinal coverage. As an oncology study, it adds to the longitudinal record of treatment development for this indication.

Status Flow

~Feb 2017 – ~Apr 2017 · 59 days · monthly snapshot~Apr 2017 – ~May 2017 · 30 days · monthly snapshot~May 2017 – ~Jul 2017 · 2 months · monthly snapshot~Jul 2017 – ~Sep 2017 · 2 months · monthly snapshot~Sep 2017 – ~Dec 2017 · 3 months · monthly snapshot~Dec 2017 – ~Jan 2018 · 31 days · monthly snapshot~Jan 2018 – ~Mar 2018 · 59 days · monthly snapshot~Mar 2018 – ~Jun 2018 · 3 months · monthly snapshot~Jun 2018 – ~Sep 2018 · 3 months · monthly snapshot~Sep 2018 – ~Dec 2018 · 3 months · monthly snapshot~Dec 2018 – ~Jul 2019 · 7 months · monthly snapshot~Jul 2019 – ~Jan 2020 · 6 months · monthly snapshot~Jan 2020 – ~Jan 2021 · 12 months · monthly snapshot~Jan 2021 – ~Feb 2021 · 31 days · monthly snapshot~Feb 2021 – ~Apr 2021 · 59 days · monthly snapshot~Apr 2021 – ~Sep 2021 · 5 months · monthly snapshot~Sep 2021 – ~Oct 2021 · 30 days · monthly snapshot~Oct 2021 – ~Mar 2022 · 5 months · monthly snapshot~Mar 2022 – ~Mar 2023 · 12 months · monthly snapshot~Mar 2023 – ~Jun 2023 · 3 months · monthly snapshot~Jun 2023 – ~Aug 2023 · 2 months · monthly snapshot~Aug 2023 – ~Sep 2023 · 31 days · monthly snapshot~Sep 2023 – ~Oct 2023 · 30 days · monthly snapshot~Oct 2023 – ~Feb 2024 · 4 months · monthly snapshot~Feb 2024 – ~Mar 2024 · 29 days · monthly snapshot~Mar 2024 – ~Apr 2024 · 31 days · monthly snapshot~Apr 2024 – ~May 2024 · 30 days · monthly snapshot~May 2024 – ~Jul 2024 · 2 months · monthly snapshot~Jul 2024 – ~Aug 2024 · 31 days · monthly snapshot~Aug 2024 – ~Sep 2024 · 31 days · monthly snapshot~Sep 2024 – ~Dec 2024 · 3 months · monthly snapshot~Dec 2024 – ~Jan 2025 · 31 days · monthly snapshot~Jan 2025 – ~Oct 2025 · 9 months · monthly snapshot~Oct 2025 – ~Nov 2025 · 31 days · monthly snapshot~Nov 2025 – present · 8 months · monthly snapshot

Change History

35 versions recorded

  1. Nov 2025 — Present [monthly]

    Recruiting PHASE1

  2. Oct 2025 — Nov 2025 [monthly]

    Recruiting PHASE1

  3. Jan 2025 — Oct 2025 [monthly]

    Recruiting PHASE1

  4. Dec 2024 — Jan 2025 [monthly]

    Recruiting PHASE1

  5. Sep 2024 — Dec 2024 [monthly]

    Recruiting PHASE1

▶ Show 30 earlier versions

  1. Aug 2024 — Sep 2024 [monthly]

    Recruiting PHASE1

  2. Jul 2024 — Aug 2024 [monthly]

    Recruiting PHASE1

  3. May 2024 — Jul 2024 [monthly]

    Recruiting PHASE1

  4. Apr 2024 — May 2024 [monthly]

    Recruiting PHASE1

  5. Mar 2024 — Apr 2024 [monthly]

    Recruiting PHASE1

  6. Feb 2024 — Mar 2024 [monthly]

    Recruiting PHASE1

  7. Oct 2023 — Feb 2024 [monthly]

    Recruiting PHASE1

  8. Sep 2023 — Oct 2023 [monthly]

    Recruiting PHASE1

  9. Aug 2023 — Sep 2023 [monthly]

    Recruiting PHASE1

  10. Jun 2023 — Aug 2023 [monthly]

    Recruiting PHASE1

  11. Mar 2023 — Jun 2023 [monthly]

    Recruiting PHASE1

  12. Mar 2022 — Mar 2023 [monthly]

    Recruiting PHASE1

  13. Oct 2021 — Mar 2022 [monthly]

    Recruiting PHASE1

  14. Sep 2021 — Oct 2021 [monthly]

    Recruiting PHASE1

  15. Apr 2021 — Sep 2021 [monthly]

    Recruiting PHASE1

  16. Feb 2021 — Apr 2021 [monthly]

    Recruiting PHASE1

  17. Jan 2021 — Feb 2021 [monthly]

    Recruiting PHASE1

  18. Jan 2020 — Jan 2021 [monthly]

    Recruiting PHASE1

  19. Jul 2019 — Jan 2020 [monthly]

    Recruiting PHASE1

    Status: Suspended → Recruiting

  20. Dec 2018 — Jul 2019 [monthly]

    Suspended PHASE1

  21. Sep 2018 — Dec 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  22. Jun 2018 — Sep 2018 [monthly]

    Recruiting PHASE1

  23. Mar 2018 — Jun 2018 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  24. Jan 2018 — Mar 2018 [monthly]

    Active Not Recruiting PHASE1

    Status: Suspended → Active Not Recruiting

  25. Dec 2017 — Jan 2018 [monthly]

    Suspended PHASE1

    Status: Recruiting → Suspended

  26. Sep 2017 — Dec 2017 [monthly]

    Recruiting PHASE1

    Status: Active Not Recruiting → Recruiting

  27. Jul 2017 — Sep 2017 [monthly]

    Active Not Recruiting PHASE1

    Status: Recruiting → Active Not Recruiting

  28. May 2017 — Jul 2017 [monthly]

    Recruiting PHASE1

    Status: Not Yet Recruiting → Recruiting

  29. Apr 2017 — May 2017 [monthly]

    Not Yet Recruiting PHASE1

  30. Feb 2017 — Apr 2017 [monthly]

    Not Yet Recruiting PHASE1

    First recorded

Eligibility Summary

No eligibility information available.

Contact Information

Sponsor contact:
  • Mayo Clinic
  • National Cancer Institute (NCI)
Data source: Mayo Clinic

For direct contact, visit the study record on ClinicalTrials.gov .

Study Locations